Androgen production in pediatric adrenocortical tumors may occur via both the classic and/or the alternative backdoor pathway
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F17%3A10373754" target="_blank" >RIV/00216208:11130/17:10373754 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/17:10373754
Result on the web
<a href="https://doi.org/10.1016/j.mce.2017.05.014" target="_blank" >https://doi.org/10.1016/j.mce.2017.05.014</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.mce.2017.05.014" target="_blank" >10.1016/j.mce.2017.05.014</a>
Alternative languages
Result language
angličtina
Original language name
Androgen production in pediatric adrenocortical tumors may occur via both the classic and/or the alternative backdoor pathway
Original language description
Children with adrenocortical tumors (ACTs) often present with virilization due to high tumoral androgen production, with dihydrotestosterone (DHT) as most potent androgen. Recent work revealed two pathways for DHT biosynthesis, the classic and the backdoor pathway. Usage of alternate routes for DHT production has been reported in castration-resistant prostate cancer, CAH and PCOS. To assess whether the backdoor pathway may contribute to the virilization of pediatric ACTs, we investigated seven children suffering from androgen producing tumors using steroid profiling and immunohistochemical expression studies. All cases produced large amounts of androgens of the classic and/or backdoor pathway. Variable expression of steroid enzymes was observed in carcinomas and adenomas. We found no discriminative pattern. This suggests that enhanced androgen production in pediatric ACTs is the result of deregulated steroidogenesis through multiple steroid pathways. Thus future treatments of ACTs targeting androgen overproduction should consider these novel steroid production pathways.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30209 - Paediatrics
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular and Cellular Endocrinology
ISSN
0303-7207
e-ISSN
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Volume of the periodical
452
Issue of the periodical within the volume
5
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
64-73
UT code for WoS article
000404794900007
EID of the result in the Scopus database
2-s2.0-85019607626