Ioduria and type 1 diabetes mellitus - Relationships to selected clinical markers of diabetes in adults

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F17%3A10373816" target="_blank" >RIV/00216208:11130/17:10373816 - isvavai.cz</a>

Alternative codes found

RIV/00023761:_____/17:N0000025 RIV/00064203:_____/17:10373816

Result on the web

<a href="https://doi.org/10.1016/j.jab.2016.11.002" target="_blank" >https://doi.org/10.1016/j.jab.2016.11.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jab.2016.11.002" target="_blank" >10.1016/j.jab.2016.11.002</a>

Result language

angličtina

Original language name

Ioduria and type 1 diabetes mellitus - Relationships to selected clinical markers of diabetes in adults

Original language description

There is a lack of data on the state of iodine reserves and the possible consequences of iodine deficits in diabetic patients. The main aims of this study were to: a) obtain information about iodine saturation in patients with type 1 diabetes; b) determine to what extent this saturation differs from the non-diabetic population; and c) determine whether iodine levels are related to several clinical and laboratory parameters characteristic of diabetic syndrome, including thyroid status. Subjects and methods: A total of 54 males and 51 females treated for type 1 diabetes mellitus (DM1) were included in this cross-sectional study. In addition to iodine saturation determined as the concentration of iodine in the first urine sample of the day, we measured clinical, anthropometric, and biochemical parameters in relation to DM1. Results: Measured iodine levels were: median 152 mu g/l, first quartile 117 mu g/l, and third quartile 219 mu g/l. More than 50% of iodine levels varied within the optimal saturation range of 100-200 mu g/l, while about 14% showed incomplete saturation (&lt; 100 mu g/l), and 34% had increased saturation (&gt; 200 mu g/l). Multi-dimensional regression showed significant positive relationships; (an OPLS model explaining 9% of the variability) between ioduria and male sex, body weight and height, and serum creatinine levels, which to date have not yet been published. Relationships to the other analyzed parameters (glycated hemoglobin, insulin dose, DM duration, body mass index, microalbuminuria, glomerular filtration rate, thyroid function and volume, thyroid autoimmune markers) were not significant. Conclusions: Iodine saturation levels in our study group were within the ICCIDD (WHO) recommendations for optimal/good saturation for the non-diabetic population, and patients with diabetic syndrome did not differ with respect to the chosen normal ioduria concentrations, i.e. 100 or 150 mu g/l. The question remains, however, whether past attempts to deal with iodine deficits in the Czech Republic are responsible for this satisfactory iodine status of the type 1 diabetic population, or if there are other factors involved.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Applied Biomedicine

ISSN

1214-021X

e-ISSN

—

Volume of the periodical

15

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

146-150

UT code for WoS article

000402479300008

EID of the result in the Scopus database

2-s2.0-85007453609