Ovarian response to 150 mu g corifollitropin alfa in a GnRH-antagonist multiple-dose protocol: a prospective cohort study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F17%3A10373818" target="_blank" >RIV/00216208:11130/17:10373818 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/17:10373818

Result on the web

<a href="https://doi.org/10.1016/j.rbmo.2017.02.012" target="_blank" >https://doi.org/10.1016/j.rbmo.2017.02.012</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.rbmo.2017.02.012" target="_blank" >10.1016/j.rbmo.2017.02.012</a>

Result language

angličtina

Original language name

Ovarian response to 150 mu g corifollitropin alfa in a GnRH-antagonist multiple-dose protocol: a prospective cohort study

Original language description

The incidence of low (&lt;6 oocytes) and high (&gt;18 oocytes) ovarian response to 150 mu g corifollitropin alfa in relation to anti-Mullerian hormone (AMH) and other biomarkers was studied in a multi-centre (n = 5), multi-national, prospective, investigator-initiated, observational cohort study. Infertile women (n = 212), body weight &gt;60 kg, underwent controlled ovarian stimulation in a gonadotrophin-releasing hormone-antagonist multiple-dose protocol. Demographic, sonographic and endocrine parameters were prospectively assessed on cycle day 2 or 3 of a spontaneous menstruation before the administration of 150 mu g corifollitropin alfa. Serum AMH showed the best correlation with the number of oocytes obtained among all predictor variables. In receiver-operating characteristic analysis, AMH at a threshold of 0.91 ng/ml showed a sensitivity of 82.4%, specificity of 82.4%, positive predictive value 52.9% and negative predictive value 95.1% for predicting low response (area under the curve [AUC], 95% CI; P-value: 0.853, 0.769-0.936; &lt;0.0001). For predicting high response, the optimal threshold for AMH was 2.58 ng/ml, relating to a sensitivity of 80.0%, specificity 82.1%, positive predictive value 42.5% and negative predictive value 96.1% (AUC, 95% CI; P-value: 0.871, 0.787-0.955; &lt;0.0001). In conclusion, patients with serum AMH concentrations between approximately 0.9 and 2.6 ng/ml were unlikely to show extremes of response. (C) 2017 Published by Elsevier Ltd on behalf of Reproductive Healthcare Ltd.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10600 - Biological sciences

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Reproductive BioMedicine Online

ISSN

1472-6483

e-ISSN

—

Volume of the periodical

34

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

534-540

UT code for WoS article

000401128200013

EID of the result in the Scopus database

2-s2.0-85014662627