Epilepsy surgery in drug resistant temporal lobe epilepsy associated with neuronal antibodies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F17%3A10373909" target="_blank" >RIV/00216208:11130/17:10373909 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/17:10373909
Result on the web
<a href="https://doi.org/10.1016/j.eplepsyres.2016.12.010" target="_blank" >https://doi.org/10.1016/j.eplepsyres.2016.12.010</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.eplepsyres.2016.12.010" target="_blank" >10.1016/j.eplepsyres.2016.12.010</a>
Alternative languages
Result language
angličtina
Original language name
Epilepsy surgery in drug resistant temporal lobe epilepsy associated with neuronal antibodies
Original language description
We assessed the outcome of patients with drug resistant epilepsy and neuronal antibodies who underwent epilepsy surgery. Retrospective study, information collected with a questionnaire sent to epilepsy surgery centers. Thirteen patients identified, with antibodies to GAD (8), Ma2 (2), Hu (1), LGI1 (1) or CASPR2 (1). Mean age at seizure onset: 23 years. Five patients had an encephalitic phase. Three had testicular tumors and five had autoimmune diseases. All had drug resistant temporal lobe epilepsy (median: 20 seizures/month). MRI showed unilateral temporal lobe abnormalities (mainly hippocampal sclerosis) in 9 patients, bilateral abnormalities in 3, and was normal in 1. Surgical procedures included anteromesial temporal lobectomy (10 patients), selective amygdalohippocampectomy (1), temporal pole resection (1) and radiofrequency ablation of mesial structures (1). Perivascular lymphocytic infiltrates were seen in 7/12 patients. One year outcome available in all patients, at 3 years in 9. At last visit 5/13 patients (38.5%) (with Ma2, Hu, LGI1, and 2 GAD antibodies) were in Engel's classes I or II. Epilepsy surgery may be an option for patients with drug resistant seizures associated with neuronal antibodies. Outcome seems to be worse than that expected in other etiologies, even in the presence of unilateral HS. Intracranial EEG may be required in some patients.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Epilepsy Research
ISSN
0920-1211
e-ISSN
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Volume of the periodical
129
Issue of the periodical within the volume
Januar
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
5
Pages from-to
101-105
UT code for WoS article
000394634300017
EID of the result in the Scopus database
2-s2.0-85007490292