Outcomes of Alcohol Septal Ablation in Younger Patients With Obstructive Hypertrophic Cardiomyopathy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F17%3A10373959" target="_blank" >RIV/00216208:11130/17:10373959 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/17:00097296 RIV/00159816:_____/17:00067088 RIV/00064203:_____/17:10373959

Result on the web

<a href="https://doi.org/10.1016/j.jcin.2017.03.030" target="_blank" >https://doi.org/10.1016/j.jcin.2017.03.030</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jcin.2017.03.030" target="_blank" >10.1016/j.jcin.2017.03.030</a>

Result language

angličtina

Original language name

Outcomes of Alcohol Septal Ablation in Younger Patients With Obstructive Hypertrophic Cardiomyopathy

Original language description

Objectives The aim of this study was to describe the safety and outcomes of alcohol septal ablation (ASA) in younger patients with obstructive hypertrophic cardiomyopathy. Background The American College of Cardiology Foundation/American Heart Association guidelines reserve ASA for older patients and patients with serious comorbidities. Data on long-term age-specific outcomes after ASA are scarce. Methods A total of 1,197 patients (mean age 58 +- 14 years) underwent ASA for obstructive hypertrophic cardiomyopathy. Patients were divided into young (LESS-THAN OR EQUAL TO50 years), middle-age (51 to 64 years), and older (GREATER-THAN OR EQUAL TO65 years) groups. Results Thirty-day mortality and pacemaker implantation rates were lower in young compared with older patients (0.3% vs. 2% [p = 0.03] and 8% vs. 16% [p &lt; 0.001], respectively). Ninety-five percent of young patients were in New York Heart Association functional class I or II at last follow-up. During a mean follow-up period of 5.4 +- 4.2 years, 165 patients (14%) died. Annual mortality rates of young, middle-age, and older patients were 1%, 2%, and 5%, respectively (p &lt; 0.01). Annual adverse arrhythmic event rates were similar in the 3 age groups at about 1% (p = 0.90). Independent predictors of mortality in young patients were age, female sex, and residual left ventricular outflow tract gradient. Additionally, young patients treated with GREATER-THAN OR EQUAL TO2.5 ml alcohol had a higher all-cause mortality rate (0.6% vs. 1.4% per year in patients treated with &lt;2.5 ml, p = 0.03). Conclusions ASA in younger patients with obstructive hypertrophic cardiomyopathy was safe and effective for relief of symptoms at long-term follow-up. The authors propose that the indication for ASA can be broadened to younger patients.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JACC: Cardiovascular Interventions

ISSN

1936-8798

e-ISSN

—

Volume of the periodical

10

Issue of the periodical within the volume

11

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

1134-1143

UT code for WoS article

000402974900013

EID of the result in the Scopus database

2-s2.0-85020231314