Recent progress of the ARegPKD registry study on autosomal recessive polycystic kidney disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F17%3A10373980" target="_blank" >RIV/00216208:11130/17:10373980 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/17:10373980

Result on the web

<a href="https://doi.org/10.3389/fped.2017.00018" target="_blank" >https://doi.org/10.3389/fped.2017.00018</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fped.2017.00018" target="_blank" >10.3389/fped.2017.00018</a>

Result language

angličtina

Original language name

Recent progress of the ARegPKD registry study on autosomal recessive polycystic kidney disease

Original language description

Autosomal recessive polycystic kidney disease (ARPKD) is a rare monogenic disease with a severe phenotype often presenting prenatally or in early childhood. With its obligate renal and hepatic involvement, ARPKD is one of the most important indications for liver and/or kidney transplantation in childhood. Marked phenotypic variability is observed, the genetic basis of which is largely unknown. Treatment is symptomatic and largely empiric as evidence-based guidelines are lacking. Therapeutic initiatives for ARPKD face the problem of highly variable cohorts and lack of clinical or biochemical risk markers without clear-cut clinical end points. ARegPKD is an international, multicenter, retro- and prospective, observational study to deeply phenotype patients with the clinical diagnosis of ARPKD. Initiated in 2013 as a web-based registry (www. aregpkd.org), ARegPKD enrolls patients across large parts of Europe and neighboring countries. By January 2017, more than 400 patients from 17 mostly European countries have been registered in the ARPKD registry study with significant follow-up data. Due to comprehensive retro- and prospective data collection and associated biobanking, ARegPKD will generate a unique ARPKD cohort with detailed longitudinal clinical characterization providing a basis for future clinical trials as well as translational research. Hence, ARegPKD is hoped to contribute to the pathophysiological understanding of the disease and to the improvement of clinical management.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30217 - Urology and nephrology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Pediatrics

ISSN

2296-2360

e-ISSN

—

Volume of the periodical

5

Issue of the periodical within the volume

February

Country of publishing house

CH - SWITZERLAND

Number of pages

6

Pages from-to

—

UT code for WoS article

000394285000001

EID of the result in the Scopus database

2-s2.0-85034265634