Sarcosine Degradation Pathway is Involved in the Epigenetics of Prostate Cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F17%3A10389377" target="_blank" >RIV/00216208:11130/17:10389377 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43210/17:43912636 RIV/00216208:11310/17:10389377 RIV/00216305:26620/17:PU128385 RIV/00064203:_____/17:10389377
Result on the web
<a href="https://mnet.mendelu.cz/mendelnet2017/mnet_2017_full.pdf" target="_blank" >https://mnet.mendelu.cz/mendelnet2017/mnet_2017_full.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Sarcosine Degradation Pathway is Involved in the Epigenetics of Prostate Cells
Original language description
It has been shown that sarcosine suplementation stimulates the proliferation of prostate cells and also their invassiveness. In present study we show that enzymes conected with sarcosine conversion to glycine (sarcosine dehydrogenase, pipecolic acid oxidase) are stimulated due to sarcosine treatment. Further, sarcosine treatment increases S-adenosylmethioneine-to-S-adenosylhomocysteine ratio, which indicates a release and utilization of free methyl groups from sarcosine degradation pathway. We identified the highest induction of global methylation in non-malignant PNT1A cells, but global methylation profiles were altered also in malignant (22Rv1) and metastatic (LNCaP) cells. The influence on methylation changes was further verified using hypomethylating agent 5-azacytidine (5-aza). Co-treatment of prostate cells with 5-aza and sarcosine resulted in decrease in cells invassiveness when compared to treatment with sarcosine alone. This correlates with sarcosine-related hypermethylation of genes involved in cells growth and cell cycle.
Czech name
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Czech description
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Project
<a href="/en/project/GA16-18917S" target="_blank" >GA16-18917S: The study of sarcosine metabolism and its participation in prostate cancer development</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Proceedings of 24Th International PhD Students Conference (Mendelnet 2017)
ISBN
978-80-7509-529-9
ISSN
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e-ISSN
neuvedeno
Number of pages
5
Pages from-to
927-931
Publisher name
MENDEL UNIV BRNO, FAC AGRONOMY
Place of publication
BRNO
Event location
Mendel Univ Brno, Fac AgriSciences, Brno
Event date
Nov 8, 2017
Type of event by nationality
CST - Celostátní akce
UT code for WoS article
000440194500166

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