Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer
Result description
In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9,040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P=4.35x10-8). Replication of ten promising signals in up to 2,737 patients and 4,752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P=8.36x10-14), rs2941471 at 8q21.11 (HNF4G, P=6.60x10-10), rs4795218 at 17q12 (HNF1B, P=1.32x10-8), and rs1517037 at 18q21.32 (GRP, P=3.28x10-8). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic datasets, provides molecular support of NOC2L as a pancreatic cancer susceptibility gene.
Keywords
The result's identifiers
Result code in IS VaVaI
Alternative codes found
RIV/68378041:_____/18:00493722 RIV/00216208:11140/18:10367235 RIV/61989592:15110/18:73590309 RIV/00209805:_____/18:00077992 RIV/61988987:17110/18:A20020QD
Result on the web
DOI - Digital Object Identifier
Alternative languages
Result language
angličtina
Original language name
Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer
Original language description
In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9,040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P=4.35x10-8). Replication of ten promising signals in up to 2,737 patients and 4,752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P=8.36x10-14), rs2941471 at 8q21.11 (HNF4G, P=6.60x10-10), rs4795218 at 17q12 (HNF1B, P=1.32x10-8), and rs1517037 at 18q21.32 (GRP, P=3.28x10-8). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic datasets, provides molecular support of NOC2L as a pancreatic cancer susceptibility gene.
Czech name
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Czech description
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Classification
Type
Jimp - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Communications [online]
ISSN
2041-1723
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
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UT code for WoS article
000424451300001
EID of the result in the Scopus database
2-s2.0-85041960929
Result type
Jimp - Article in a specialist periodical, which is included in the Web of Science database
OECD FORD
Oncology
Year of implementation
2018