IKZF1(plus) Defines a New Minimal Residual Disease-Dependent Very-Poor Prognostic Profile in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F18%3A10375286" target="_blank" >RIV/00216208:11130/18:10375286 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/18:10375286

Result on the web

<a href="https://doi.org/10.1200/JCO.2017.74.3617" target="_blank" >https://doi.org/10.1200/JCO.2017.74.3617</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1200/JCO.2017.74.3617" target="_blank" >10.1200/JCO.2017.74.3617</a>

Result language

angličtina

Original language name

IKZF1(plus) Defines a New Minimal Residual Disease-Dependent Very-Poor Prognostic Profile in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

Original language description

PurposeSomatic deletions that affect the lymphoid transcription factor-coding gene IKZF1 have previously been reported as independently associated with a poor prognosis in pediatric B-cell precursor (BCP) acute lymphoblastic leukemia (ALL). We have now refined the prognostic strength of IKZF1 deletions by analyzing the effect of co-occurring deletions.Patients and MethodsThe analysis involved 991 patients with BCP ALL treated in the Associazione Italiana Ematologia ed Oncologia Pediatrica-Berlin-Frankfurt-Muenster (AIEOP-BFM) ALL 2000 trial with complete information for copy number alterations of IKZF1, PAX5, ETV6, RB1, BTG1, EBF1, CDKN2A, CDKN2B, Xp22.33/Yp11.31 (PAR1 region; CRLF2, CSF2RA, and IL3RA), and ERG; replication of findings involved 417 patients from the same trial.ResultsIKZF1 deletions that co-occurred with deletions in CDKN2A, CDKN2B, PAX5, or PAR1 in the absence of ERG deletion conferred the worst outcome and, consequently, were grouped as IKZF1(plus). The IKZF1(plus) group comprised 6% of patients with BCP ALL, with a 5-year event-free survival of 53 6% compared with 79 +/- 5% in patients with IKZF1 deletion who did not fulfill the IKZF1(plus) definition and 87 +/- 1% in patients who lacked an IKZF1 deletion (P .001). Respective 5-year cumulative relapse incidence rates were 44 +/- 6%, 11 +/- 4%, and 10 +/- 1% (P .001). Results were confirmed in the replication cohort, and multivariable analyses demonstrated independence of IKZF1(plus). The IKZF1(plus) prognostic effect differed dramatically in analyses stratified by minimal residual disease (MRD) levels after induction treatment: 5-year event-free survival for MRD standard-risk IKZF1(plus) patients was 94 +/- 5% versus 40 +/- 10% in MRD intermediate- and 30 +/- 14% in high-risk IKZF1(plus) patients (P .001). Corresponding 5-year cumulative incidence of relapse rates were 6 +/- 6%, 60 +/- 10%, and 60 +/- 17% (P .001).ConclusionIKZF1(plus) describes a new MRD-dependent very-poor prognostic profile in BCP ALL. Because current AIEOP-BFM treatment is largely ineffective for MRD-positive IKZF1(plus) patients, new experimental treatment approaches will be evaluated in our upcoming trial AIEOP-BFM ALL 2017.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

<a href="/en/project/GJ15-06049Y" target="_blank" >GJ15-06049Y: Functional characterization of aberrant ERG in hematopoiesis and leukemia</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Clinical Oncology

ISSN

0732-183X

e-ISSN

—

Volume of the periodical

36

Issue of the periodical within the volume

12

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

1240-1249

UT code for WoS article

000430459900009

EID of the result in the Scopus database

2-s2.0-85045626043