Spatial navigation deficits in amnestic mild cognitive impairment with neuropsychiatric comorbidity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F18%3A10375334" target="_blank" >RIV/00216208:11130/18:10375334 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/18:00489956 RIV/00159816:_____/18:00067044 RIV/00064203:_____/18:10375334
Result on the web
<a href="https://doi.org/10.1080/13825585.2017.1290212" target="_blank" >https://doi.org/10.1080/13825585.2017.1290212</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/13825585.2017.1290212" target="_blank" >10.1080/13825585.2017.1290212</a>

Result language
angličtina
Original language name
Spatial navigation deficits in amnestic mild cognitive impairment with neuropsychiatric comorbidity
Original language description
Aims: To find out whether neuropsychiatric comorbidity (comMCI) influences spatial navigation performance in amnestic mild cognitive impairment (aMCI).Methods: We recruited aMCI patients with (n=21) and without (n=21) neuropsychiatric comorbidity or alcohol abuse, matched for global cognitive impairment and cognitively healthy elderly participants (HE, n=22). They completed the Mini-Mental State Examination and a virtual Hidden Goal Task in egocentric, allocentric, and delayed recall subtests.Results: In allocentric navigation, aMCI and comMCI performed significantly worse than HE and similarly to each other. Although aMCI performed significantly worse at egocentric navigation than HE, they performed significantly better than patients with comMCI.Conclusions: Despite the growing burden of dementia and the prevalence of neuropsychiatric symptoms in the elderly population, comMCI remains under-studied. Since trials often assess pure aMCI, we may underestimate patients' navigation and other deficits. This finding emphasizes the importance of taking account of the cognitive effects of psychiatric disorders in aMCI.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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