Differences in Urinary Amino Acid Patterns in Individuals with Different Types of Urological Tumor Urinary Amino Acid Patterns as Markers of Urological Tumors

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F18%3A10375364" target="_blank" >RIV/00216208:11130/18:10375364 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43210/18:43913619 RIV/00216305:26620/18:PU127989 RIV/00064203:_____/18:10375364
Result on the web
<a href="https://doi.org/10.21873/invivo.11257" target="_blank" >https://doi.org/10.21873/invivo.11257</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.21873/invivo.11257" target="_blank" >10.21873/invivo.11257</a>

Result language
angličtina
Original language name
Differences in Urinary Amino Acid Patterns in Individuals with Different Types of Urological Tumor Urinary Amino Acid Patterns as Markers of Urological Tumors
Original language description
Background: Insufficient specificity and invasiveness of currently used diagnostic methods raises the need for new markers of urological tumors. The aim of this study was to find a link between the urinary excretion of amino acids and the presence of urological tumors. Materials and Methods: Using ion-exchange chromatography, we tested urine samples of patients with prostate cancer (n = 30), urinary bladder cancer (n = 28), renal cell carcinoma (n = 16) and healthy volunteers (control group; n = 21). Results: In each category, we found a group of amino acids which differed in concentration compared to the control group. These differences were most significant in sarcosine in patients with prostate cancer; leucine, phenylalanine and arginine in those with bladder cancer; and sarcosine, glutamic acid, glycine, tyrosine and arginine in the those with renal cell carcinoma. Conclusion: Results of our research imply a possible connection between the occurrence of specific types of amino acids in the urine and the presence of urological tumors.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30217 - Urology and nephrology

Project
<a href="/en/project/NV15-33910A" target="_blank" >NV15-33910A: Laboratory and clinical testing of candidate markers for prostate cancer using samples from a complex cryobank of patients with long-term follow-up.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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