Life-Threatening Event Risk in Children With Wolff-Parkinson-White Syndrome: A Multicenter International Study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F18%3A10375536" target="_blank" >RIV/00216208:11130/18:10375536 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/18:10375536

Result on the web

<a href="https://doi.org/10.1016/j.jacep.2017.10.009" target="_blank" >https://doi.org/10.1016/j.jacep.2017.10.009</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jacep.2017.10.009" target="_blank" >10.1016/j.jacep.2017.10.009</a>

Result language

angličtina

Original language name

Life-Threatening Event Risk in Children With Wolff-Parkinson-White Syndrome: A Multicenter International Study

Original language description

Objectives: This study sought to characterize risk in children with Wolff-Parkinson-White (WPW) syndrome by comparing those who had experienced a life-threatening event (LTE) with a control population. Background: Children with WPW syndrome are at risk of sudden death. Methods: This retrospective multicenter pediatric study identified 912 subjects LESS-THAN OR EQUAL TO21 years of age with WPW syndrome, using electrophysiology (EPS) studies. Case subjects had a history of LTE: sudden death, aborted sudden death, or atrial fibrillation (shortest pre-excited RR interval in atrial fibrillation [SPERRI] of LESS-THAN OR EQUAL TO250 ms or with hemodynamic compromise); whereas subjects did not. We compared clinical and EPS data between cases and subjects. Results: Case subjects (n = 96) were older and less likely than subjects (n = 816) to have symptoms or documented tachycardia. Mean age at LTE was 14.1 +- 3.9 years of age. The LTE was the sentinel symptom in 65%, consisting of rapidly conducted pre-excited atrial fibrillation (49%), aborted sudden death (45%), and sudden death (6%). Three risk components were considered at EPS: SPERRI, accessory pathway effective refractory period (APERP), and shortest paced cycle length with pre-excitation during atrial pacing (SPPCL), and all were shorter in cases than in control subjects. In multivariate analysis, risk factors for LTE included male sex, Ebstein malformation, rapid anterograde conduction (APERP, SPERRI, or SPPCL LESS-THAN OR EQUAL TO250 ms), multiple pathways, and inducible atrial fibrillation. Of case subjects, 60 of 86 (69%) had GREATER-THAN OR EQUAL TO2 EPS risk stratification components performed; 22 of 60 (37%) did not have EPS-determined high-risk characteristics, and 15 of 60 (25%) had neither concerning pathway characteristics nor inducible atrioventricular reciprocating tachycardia. Conclusions: Young patients may experience LTE from WPW syndrome without prior symptoms or markers of high-risk on EPS.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JACC: Clinical Electrophysiology [online]

ISSN

2405-500X

e-ISSN

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Volume of the periodical

4

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

433-444

UT code for WoS article

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EID of the result in the Scopus database

2-s2.0-85034441724