Osteoinductive 3D scaffolds prepared by blend centrifugal spinning for long-term delivery of osteogenic supplements

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F18%3A10376395" target="_blank" >RIV/00216208:11130/18:10376395 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21720/18:00327466 RIV/00216208:11140/18:10376395 RIV/00216208:11310/18:10376395 RIV/68378041:_____/18:00522983

Result on the web

<a href="https://doi.org/10.1039/c8ra02735h" target="_blank" >https://doi.org/10.1039/c8ra02735h</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c8ra02735h" target="_blank" >10.1039/c8ra02735h</a>

Result language

angličtina

Original language name

Osteoinductive 3D scaffolds prepared by blend centrifugal spinning for long-term delivery of osteogenic supplements

Original language description

Bone regeneration is a long-term process requiring proper scaffolding and drug delivery systems. The current study delivers a three-dimensional (3D) scaffold prepared by blend centrifugal spinning loaded with the osteogenic supplements (OS) β-glycerol phosphate, ascorbate-2-phosphate and dexamethasone. The OS were successfully encapsulated into a fibrous scaffold and showed sustained release for 30 days. Furthermore, biological testing showed the osteoinductive properties of the scaffolds on a model of human mesenchymal stem cells and stimulatory effect on a model of osteoblasts. The osteoinductive properties were further proved in vivo in critical size defects of rabbits. The amount of bone trabecules was bigger compared to control fibers without OS. The results indicate that due to its long-term drug releasing properties, single step fabrication process and 3D structure, the system shows ideal properties for use as a cell-free bone implant in tissue-engineering. (C) 2018 The Royal Society of Chemistry.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

RSC Advances

ISSN

2046-2069

e-ISSN

—

Volume of the periodical

8

Issue of the periodical within the volume

39

Country of publishing house

GB - UNITED KINGDOM

Number of pages

16

Pages from-to

21889-21904

UT code for WoS article

000436031800026

EID of the result in the Scopus database

2-s2.0-85048810942