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Osteoinductive 3D scaffolds prepared by blend centrifugal spinning for long-term delivery of osteogenic supplements

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F18%3A10376395" target="_blank" >RIV/00216208:11130/18:10376395 - isvavai.cz</a>

  • Alternative codes found

    RIV/68407700:21720/18:00327466 RIV/00216208:11140/18:10376395 RIV/00216208:11310/18:10376395 RIV/68378041:_____/18:00522983

  • Result on the web

    <a href="https://doi.org/10.1039/c8ra02735h" target="_blank" >https://doi.org/10.1039/c8ra02735h</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1039/c8ra02735h" target="_blank" >10.1039/c8ra02735h</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Osteoinductive 3D scaffolds prepared by blend centrifugal spinning for long-term delivery of osteogenic supplements

  • Original language description

    Bone regeneration is a long-term process requiring proper scaffolding and drug delivery systems. The current study delivers a three-dimensional (3D) scaffold prepared by blend centrifugal spinning loaded with the osteogenic supplements (OS) β-glycerol phosphate, ascorbate-2-phosphate and dexamethasone. The OS were successfully encapsulated into a fibrous scaffold and showed sustained release for 30 days. Furthermore, biological testing showed the osteoinductive properties of the scaffolds on a model of human mesenchymal stem cells and stimulatory effect on a model of osteoblasts. The osteoinductive properties were further proved in vivo in critical size defects of rabbits. The amount of bone trabecules was bigger compared to control fibers without OS. The results indicate that due to its long-term drug releasing properties, single step fabrication process and 3D structure, the system shows ideal properties for use as a cell-free bone implant in tissue-engineering. (C) 2018 The Royal Society of Chemistry.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    RSC Advances

  • ISSN

    2046-2069

  • e-ISSN

  • Volume of the periodical

    8

  • Issue of the periodical within the volume

    39

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    16

  • Pages from-to

    21889-21904

  • UT code for WoS article

    000436031800026

  • EID of the result in the Scopus database

    2-s2.0-85048810942