Risk Factors for Early Dialysis Dependency in Autosomal Recessive Polycystic Kidney Disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F18%3A10376817" target="_blank" >RIV/00216208:11130/18:10376817 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/18:10376817
Result on the web
<a href="https://doi.org/10.1016/j.jpeds.2018.03.052" target="_blank" >https://doi.org/10.1016/j.jpeds.2018.03.052</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jpeds.2018.03.052" target="_blank" >10.1016/j.jpeds.2018.03.052</a>
Alternative languages
Result language
angličtina
Original language name
Risk Factors for Early Dialysis Dependency in Autosomal Recessive Polycystic Kidney Disease
Original language description
Objective To identify prenatal, perinatal, and postnatal risk factors for dialysis within the first year of life in children with autosomal recessive polycystic kidney disease (ARPKD) as a basis for parental counseling after prenatal and perinatal diagnosis. Study design A dataset comprising 385 patients from the ARegPKD international registry study was analyzed for potential risk markers for dialysis during the first year of life. Results Thirty-six out of 385 children (9.4%) commenced dialysis in the first year of life. According to multivariable Cox regression analysis, the presence of oligohydramnios or anhydramnios, prenatal kidney enlargement, a low Apgar score, and the need for postnatal breathing support were independently associated with an increased hazard ratio for requiring dialysis within the first year of life. The increased risk associated with Apgar score and perinatal assisted breathing was time-dependent and vanished after 5 and 8 months of life, respectively. The predicted probabilities for early dialysis varied from 1.5% (95% CI, 0.5%-4.1%) for patients with ARPKD with no prenatal sonographic abnormalities to 32.3% (95% CI, 22.2%-44.5%) in cases of documented oligohydramnios or anhydramnios, renal cysts, and enlarged kidneys. Conclusions This study, which identified risk factors associated with onset of dialysis in ARPKD in the first year of life. may be helpful in prenatal parental counseling in cases of suspected ARPKD.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30217 - Urology and nephrology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Pediatrics
ISSN
0022-3476
e-ISSN
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Volume of the periodical
199
Issue of the periodical within the volume
August
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
22-28
UT code for WoS article
000439478200007
EID of the result in the Scopus database
2-s2.0-85046668768