An undifferentiated sarcoma with BCOR-CCNB3 fusion transcript - pathological and clinical retrospective study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F18%3A10377419" target="_blank" >RIV/00216208:11130/18:10377419 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/18:10377419

Result on the web

<a href="https://doi.org/10.4149/neo_2018_171107N716" target="_blank" >https://doi.org/10.4149/neo_2018_171107N716</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/neo_2018_171107N716" target="_blank" >10.4149/neo_2018_171107N716</a>

Result language

angličtina

Original language name

An undifferentiated sarcoma with BCOR-CCNB3 fusion transcript - pathological and clinical retrospective study

Original language description

The BCOR-CCNB3 positive sarcoma is a recently identified sarcoma morphologically and clinically similar to Ewing sarcoma in adolescents and young adults. The BCOR-CCNB3 fusion transcript originates from a paracentric inversion on the X chromosome with an in-frame fusion between the last codon of BCOR and the exon 5 of CCNB3 gene. We report morphological and molecular genetic analysis of 8 undifferentiated sarcomas positive for the BCOR-CCNB3 fusion. Six of the eight BCOR-CCNB3 positive sarcoma patients were male. Five of the eight patients were in their second decade of life (median of all patients 14 years at diagnosis). The bone marrow involvement was demonstrated in 2 of 4 patients tested. Detection of the fusion transcripts BCOR-CCNB3 in the bone marrow suggests that patients with positive findings are at high risk of the tumor progression.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30109 - Pathology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neoplasma

ISSN

0028-2685

e-ISSN

—

Volume of the periodical

65

Issue of the periodical within the volume

4

Country of publishing house

SK - SLOVAKIA

Number of pages

7

Pages from-to

630-636

UT code for WoS article

000440172400018

EID of the result in the Scopus database

2-s2.0-85051273571