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Higher Total Insulin Dose Has Positive Effect on Corneal Nerve Fibers in DM1 Patients

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F18%3A10377566" target="_blank" >RIV/00216208:11130/18:10377566 - isvavai.cz</a>

  • Alternative codes found

    RIV/00064203:_____/18:10377566

  • Result on the web

    <a href="https://doi.org/10.1167/iovs.18-24265" target="_blank" >https://doi.org/10.1167/iovs.18-24265</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1167/iovs.18-24265" target="_blank" >10.1167/iovs.18-24265</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Higher Total Insulin Dose Has Positive Effect on Corneal Nerve Fibers in DM1 Patients

  • Original language description

    PURPOSE. Neuropathies are among the most common long-term complications of diabetes mellitus (DM) and good glycemic control is essential in prevention of this complication. DM patients with similar mean glucose levels or HbA1c levels often exhibit differences in glucose variability. We tested for possible associations between parameters of glycemia compensation and corneal sub-basal nerve fiber status. METHODS. The study included 20 patients with DM type 1 treated using an intensified insulin regimen. The corneas of both eyes were examined using in vivo corneal confocal microscopy. Corneal nerve fiber density (NFD), nerve fiber length (NFL), and nerve branch density (NBD) were evaluated. Possible associations between parameters of glycemia compensation (HbA1c, glycemia SD, and insulin dose), and other clinical factors were analyzed. RESULTS. NBD was the highest in those with higher glycemic variability (P = 0.023). HbA1c had a negligible effect on corneal nerve parameters. NFD, NFL, and NBD were statistically significantly higher in those with higher total insulin per kilogram (P = 0.02, P = 0.01, and P = 0.012, respectively). Among other factors, a positive correlation between free thyroxine (fT4) levels and NFD and NBD was also found (P = 0.041 and P = 0.015, respectively). CONCLUSIONS. Total insulin dose per kilogram may be an important factor influencing nerve fiber status and needs to be considered in future studies of diabetic neuropathy pathophysiology and its progression. Also, more attention must be paid to other possible factors when elucidating the development of diabetic complications.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30207 - Ophthalmology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Investigative Ophthalmology and Visual Science

  • ISSN

    0146-0404

  • e-ISSN

  • Volume of the periodical

    59

  • Issue of the periodical within the volume

    10

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    8

  • Pages from-to

    3800-3807

  • UT code for WoS article

    000441273800002

  • EID of the result in the Scopus database

    2-s2.0-85051214544