Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F18%3A10380363" target="_blank" >RIV/00216208:11130/18:10380363 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/18:73589223

Result on the web

<a href="https://doi.org/10.1038/s41467-018-05890-2" target="_blank" >https://doi.org/10.1038/s41467-018-05890-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41467-018-05890-2" target="_blank" >10.1038/s41467-018-05890-2</a>

Result language

angličtina

Original language name

Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity

Original language description

Lung cancer has several genetic associations identified within the major histocompatibility complex (MHC); although the basis for these associations remains elusive. Here, we analyze MHC genetic variation among 26,044 lung cancer patients and 20,836 controls densely genotyped across the MHC, using the Illumina Illumina OncoArray or Illumina 660W SNP microarray. We impute sequence variation in classical HLA genes, fine-map MHC associations for lung cancer risk with major histologies and compare results between ethnicities. Independent and novel associations within HLA genes are identified in Europeans including amino acids in the HLA-B*0801 peptide binding groove and an independent HLA-DQB1*06 loci group. In Asians, associations are driven by two independent HLA allele sets that both increase risk in HLA-DQB1*0401 and HLA-DRB1*0701; the latter better represented by the amino acid Ala-104. These results implicate several HLA-tumor peptide interactions as the major MHC factor modulating lung cancer susceptibility.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30502 - Other medical science

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature Communications [online]

ISSN

2041-1723

e-ISSN

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Volume of the periodical

9

Issue of the periodical within the volume

September

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

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UT code for WoS article

000445562800006

EID of the result in the Scopus database

2-s2.0-85053845843