Fecal calprotectin is not a clinically useful marker for the prediction of the early nonresponse to exclusive enteral nutrition in pediatric patients with Crohn disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F18%3A10381192" target="_blank" >RIV/00216208:11130/18:10381192 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/18:10381192
Result on the web
<a href="https://doi.org/10.1007/s00431-018-3228-5" target="_blank" >https://doi.org/10.1007/s00431-018-3228-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00431-018-3228-5" target="_blank" >10.1007/s00431-018-3228-5</a>
Alternative languages
Result language
angličtina
Original language name
Fecal calprotectin is not a clinically useful marker for the prediction of the early nonresponse to exclusive enteral nutrition in pediatric patients with Crohn disease
Original language description
Exclusive enteral nutrition (EEN) has been recommended as the first-line therapy in children with active Crohn disease (CD). The primary aim of our study was to determine whether it is possible to use the difference between basal fecal calprotectin (F-CPT) and the value at week 2 of EEN to predict clinical response at week 6. We prospectively collected stool samples for F-CPT analysis and clinical and laboratory parameters during EEN from 38 pediatric patients (28 boys, median age 12.8years) with newly diagnosed active luminal CD. The difference between F-CPT concentrations before EEN and at week 2 did not predict clinical non-response at week 6 (OR 0.9996 95% CI 0.9989-1.0002, p=0.18); however, it predicted patients who did not achieve clinical remission at week 6 (OR 0.9993, 95% CI 00.9985-0.9998, p=0.006) with sensitivity of 58%, and specificity of 92% for cut-off of F-CPT increase by 486g/g.Conclusions: An early decrease in F-CPT levels in children with newly diagnosed active luminal CD did not predict clinical response at week 6 of EEN induction therapy, and clinical remission was predicted with low accuracy. Therefore, F-CPT cannot be used as a predictor to select the patients in whom EEN should be terminated.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30209 - Paediatrics
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Pediatrics
ISSN
0340-6199
e-ISSN
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Volume of the periodical
177
Issue of the periodical within the volume
11
Country of publishing house
DE - GERMANY
Number of pages
9
Pages from-to
1685-1693
UT code for WoS article
000447379700013
EID of the result in the Scopus database
2-s2.0-85054891140