Validation of the HCM Risk-SCD model in patients with hypertrophic cardiomyopathy following alcohol septal ablation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F18%3A10383523" target="_blank" >RIV/00216208:11130/18:10383523 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/18:10383523

Result on the web

<a href="https://doi.org/10.1093/europace/eux251" target="_blank" >https://doi.org/10.1093/europace/eux251</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/europace/eux251" target="_blank" >10.1093/europace/eux251</a>

Result language

angličtina

Original language name

Validation of the HCM Risk-SCD model in patients with hypertrophic cardiomyopathy following alcohol septal ablation

Original language description

Aims The HCM Risk-SCD model for prediction of sudden cardiac death (SCD) in hypertrophic cardiomyopathy recom- mended by the 2014 European Society of Cardiology (ESC) guidelines has not been validated after septal reduction therapy. The aim of this study was to validate the HCM Risk-SCD model in patients undergoing alcohol septal ablation (ASA) and to compare its performance to previous models. Methods and results A total of 844 ASA patients without prior SCD event were included. The primary endpoint was a composite of SCD and result and appropriate implantable cardioverter defibrillator (ICD) therapy, identical to the HCM Risk-SCD endpoint. A distinction between periprocedural (&lt;= 30 days) and long-term (&gt;30 days) SCD was made to discern procedure-related adverse arrhythmic events caused by the ASA-induced myocardial infarction from long-term SCD risk. Twenty patients reached the SCD endpoint within the first 30 days. During a follow-up of 6.5 +/- 4.2 years, another 46 patients reached the SCD endpoint. The predicted 5-year SCD risk according to the HCM Risk-SCD model was 5.1%, and the observed 5-year SCD risk was 4.0%. The C-statistics for the use of the HCM Risk-SCD model was 0.61 (P = 0.02), the C-statistics for the use of the 2003 American College of Cardiology/ESC guidelines was 0.59 (P= 0.051), and the C-statistic for the use of the 2011 American College of Cardiology Foundation/American Heart Association guidelines was 0.58 (P= 0.054). Maximal left ventricular wall thickness, syncope after ASA, and fulfilling the 2014 ESC recommendations for primary ICD implantation according to the HCM Risk-SCD model, respectively, predicted SCD during tong-term follow-up. Conclusion The HCM Risk-SCD model can be used for SCD prediction in patients undergoing ASA.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Europace

ISSN

1099-5129

e-ISSN

—

Volume of the periodical

20

Issue of the periodical within the volume

September

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

"F198"-"F203"

UT code for WoS article

000450396600010

EID of the result in the Scopus database

2-s2.0-85059109626