The use of estradiol metered-dose transdermal spray in clinical practice

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F18%3A10387154" target="_blank" >RIV/00216208:11130/18:10387154 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/18:10387154 RIV/75010330:_____/18:00012331
Result on the web
<a href="https://doi.org/10.1080/13697137.2018.1504916" target="_blank" >https://doi.org/10.1080/13697137.2018.1504916</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/13697137.2018.1504916" target="_blank" >10.1080/13697137.2018.1504916</a>

Result language
angličtina
Original language name
The use of estradiol metered-dose transdermal spray in clinical practice
Original language description
Objective: The aim of this study was to evaluate the use of novel estradiol metered-dose transdermal spray (EMDTS) in the treatment of acute climacteric syndrome. Methods: A multicenter open-label trial was conducted with a 24-week intervention. EMDTS 1.53 mg was given to symptomatic menopausal women. The Menopause Rating Scale (MRS) was used to assess the climacteric syndrome severity. The Friedman non-parametric test and a post-hoc test with Bonferroni correction were used for statistical evaluation. Results: A total of 132 women were enrolled in 20 centers, of whom 123 (93.2%) completed the study. The average age of patients was 53.8 years (37-65 years). The study was discontinued by 6.8% of women. The patients were checked at the beginning of the study, and after 12 and 24 weeks. There was a statistically significant drop (p < 0.001) in MRS values both after 12 and 24 weeks of therapy. The average MRS values improved by 66.2% between the first and the third visits. The most significant improvement was manifested in patients with initial moderate climacteric syndrome (70.9%). Conclusion: This study confirms that application of EMDTS offers a novel treatment option for climacteric symptoms.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30214 - Obstetrics and gynaecology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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