The long non-coding RNA landscape in juvenile myelomonocytic leukemia

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F18%3A10387159" target="_blank" >RIV/00216208:11130/18:10387159 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/18:10387159
Result on the web
<a href="https://doi.org/10.3324/haematol.2018.189977" target="_blank" >https://doi.org/10.3324/haematol.2018.189977</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3324/haematol.2018.189977" target="_blank" >10.3324/haematol.2018.189977</a>

Result language
angličtina
Original language name
The long non-coding RNA landscape in juvenile myelomonocytic leukemia
Original language description
We documented for the first time the lncRNA landscape in 44 JMML patients and have associated lncRNA expression with clinical and molecular characteristics. We demonstrated that JMML patients exhibit a distinct lncRNA expression profile compared to healthy controls and different JMML subgroups have distinct lncRNA signatures contributing to disease heterogeneity. Follow-up studies are needed to confirm the prognostic value of lncRNAs and to perform an integrative analysis of lncRNA expression profiles with mutational patterns, DNA methylation profiles and clinical patients' characteristics. This study paves the way for further functional research on the role of lncRNAs in JMML biology, and their diagnostic and therapeutic application.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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