Anti-inflammatory compound curcumin and mesenchymal stem cells in the treatment of spinal cord injury in rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F18%3A10387175" target="_blank" >RIV/00216208:11130/18:10387175 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/18:00507350

Result on the web

<a href="https://doi.org/10.21307/ane-2018-035" target="_blank" >https://doi.org/10.21307/ane-2018-035</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21307/ane-2018-035" target="_blank" >10.21307/ane-2018-035</a>

Result language

angličtina

Original language name

Anti-inflammatory compound curcumin and mesenchymal stem cells in the treatment of spinal cord injury in rats

Original language description

Spinal cord injury leads to a robust inflammatory response that Is an unfavorable environment for stem cell implantation. In this study, we evaluated the effect of combined therapy of curcumin and mesenchymal stem cells (MSC) on behavioral recovery and tissue sparing, glial scar formation, axonal sprouting and inflammatory responses in a rat experimental model of spinal cord injury (SCI). Balloon-induced compression lesion was performed at thoracic (Th8-9) spinal level. Out of the four groups studied, two groups received curcumin on the surface of the spinal cord immediately after SCI and then once a week for 3 weeks together with an intraperitoneal daily curcumin injection for 28 days. The other two groups received saline. Seven days after SCI, human MSC were intrathecally implanted in one curcumin and one saline group. Both curcumin and curcumin combined with MSC treatment improved locomotor ability in comparison to the saline treated animals. The combined treatment group showed additional improvement in advanced locomotor performance. The combined therapy facilitated axonal sprouting, and modulated expression of pro-regenerative factors and inflammatory responses, when compared to saline and single treatments. These results demonstrate that preconditioning with curcumin, prior to the MSC implantation could have a synergic effect in the treatment of experimental SCI.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Neurobiologiae Experimentalis

ISSN

0065-1400

e-ISSN

—

Volume of the periodical

78

Issue of the periodical within the volume

4

Country of publishing house

PL - POLAND

Number of pages

17

Pages from-to

358-374

UT code for WoS article

000454991600009

EID of the result in the Scopus database

2-s2.0-85059796951