Poly-ϵ-caprolactone and polyvinyl alcohol electrospun wound dressings: Adhesion properties and wound management of skin defects in rabbits

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F19%3A10395639" target="_blank" >RIV/00216208:11130/19:10395639 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/19:10395639 RIV/00216208:11510/19:10395639
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=lZshW4yQwF" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=lZshW4yQwF</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2217/rme-2018-0072" target="_blank" >10.2217/rme-2018-0072</a>

Result language
angličtina
Original language name
Poly-ϵ-caprolactone and polyvinyl alcohol electrospun wound dressings: Adhesion properties and wound management of skin defects in rabbits
Original language description
Aim: This study evaluates the effect of electrospun dressings in critical sized full-thickness skin defects in rabbits. Materials & methods: Electrospun poly-ϵ-caprolactone (PCL) and polyvinyl alcohol (PVA) nanofibers were tested in vitro and in vivo. Results: The PCL scaffold supported the proliferation of mesenchymal stem cells, fibroblasts and keratinocytes. The PVA scaffold showed significant swelling, high elongation capacity, limited protein adsorption and stimulation of cells. Nanofibrous dressings improved wound healing compared with the control group in vivo. A change of the PCL dressing every 7 days resulted in a decreased epithelial thickness and type I collagen level in the adhesive group, indicating peeling off of the newly formed tissue. In the PVA dressings, the exchange did not affect healing. Conclusion: The results demonstrate the importance of proper dressing exchange. (C) 2019 Future Medicine Ltd.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10610 - Biophysics

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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