Clinical utility of FLNC variants identified in 4 young Czech people with sudden cardiac arrest for clinical management of their at risk relatives

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F19%3A10396190" target="_blank" >RIV/00216208:11130/19:10396190 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Clinical utility of FLNC variants identified in 4 young Czech people with sudden cardiac arrest for clinical management of their at risk relatives

Original language description

Introduction: Mutations in FLNC gene were initially related to muscular dystrophy and myofibrillar myopathy but more recently, variants in FLNC were reported to cause familial cardiomyopathies in the absence of skeletal muscle defects. Truncating mutations in FLNC cause an overlapping phenotype of dilated cardiomyopathy or arrhythmogenic cardiomyopathy while missense mutations are associated with familiar hypertrophic cardiomyopathy and might also play an important role in cases of unexplained sudden cardiac death (SCD) in young subjects. Materials and Methods: We investigated the cohort of Czech cardiac arrest (CA) survivors/victims by performing massively parallel sequencing using a custom-made panel comprising 229 cardiac conditions-related genes (NimbleGen/Illumina). Detected variants were validated by Sanger sequencing, including their familial segregation and classified according to ACMG. Results: We have identified variants in FLNC gene in 3 cases. In 2/3 cases the rare variant NM_001458.4 (FLNC):c.102G&gt;A p.(Trp34*) was found in non-related Czech subjects (26 years old male CA victim and 16 years old female CA survivor). NM_001458.4 (FLNC):c.1732G&gt;T p.(Gly578Cys) in CA victim, where this variant was coexistent with probable causative variant in TTN gene. Conclusion: Both, truncating and missense mutations in the FLNC gene might be associated with SCA and demonstrate the clinical utility of genetic testing in at-risk family members. The aim of our study is to increase the usage of genetic analysis in post mortem investigations of SCD in the young cases in order to improve clinical management of relatives at risk in the Czech Republic.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

10600 - Biological sciences

Project

<a href="/en/project/NV18-02-00237" target="_blank" >NV18-02-00237: Detection of sudden cardiac death causes in people aged 0-35 years using molecular genetic methods – a pilot study</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů