Tyrosinase immunohistochemistry can be employed for the diagnosis of atypical teratoid/rhabdoid tumours of the tyrosinase subgroup (ATRT-TYR)
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10395652" target="_blank" >RIV/00216208:11130/20:10395652 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/20:10395652
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ay-4Xmwbg0" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ay-4Xmwbg0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/nan.12560" target="_blank" >10.1111/nan.12560</a>
Alternative languages
Result language
angličtina
Original language name
Tyrosinase immunohistochemistry can be employed for the diagnosis of atypical teratoid/rhabdoid tumours of the tyrosinase subgroup (ATRT-TYR)
Original language description
Atypical teratoid/rhabdoid tumour (ATRT) is a malignant brain tumour mainly occurring in young children. Mutations of chromatin remodelling complex member SMARCB1/INI1 or (rarely) SMARCA4/BRG1 are the sole recurrent genetic lesions. On an epigenetic level, however, ATRT is a heterogeneous disease comprised of three different molecular subgroups (ATRT-TYR, ATRT-SHH and ATRT-MYC). These subgroups are characterized by distinct DNA methylome profiles, enhancer landscapes and subgroup-specific transcriptional networks. Because molecular subgroups not only differ with regard to tumour location and age of onset, but may also show differences in overall survival, molecular subgrouping of ATRT is expected to influence clinical management. This holds especially true for the identification of ATRT-TYR, a subgroup named after the enzyme tyrosinase, which is highly expressed in this subgroup. ATRT-TYR tumours are further characterized by overexpression of melanosomal marker genes (e.g. TYR, TYRP and MITF) and OTX2, young age of onset, infratentorial location and relatively favourable outcome. DNA methylation profiling is a robust and reliable tool for the molecular classification of brain tumours 9 and has been successfully employed for subgrouping of ATRT. However, availability and/or legal regulations preclude first-line use of DNA methylation profiling at some institutions. We have previously shown that tyrosinase is overexpressed at the mRNA and protein level in ATRT-TYR, but the sensitivity and specificity of tyrosinase immunohistochemistry for the diagnosis of ATRT-TYR have not yet been determined. Here, we show in a large ATRT series with known molecular subgroup status that positive tyrosinase staining is highly specific for the diagnosis of ATRT-TYR.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neuropathology and Applied Neurobiology
ISSN
0305-1846
e-ISSN
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Volume of the periodical
46
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
4
Pages from-to
186-189
UT code for WoS article
000476070700001
EID of the result in the Scopus database
2-s2.0-85069903175