Is Engrailed-2 (EN2) a truly promising biomarker in prostate cancer detection?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10400512" target="_blank" >RIV/00216208:11130/20:10400512 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/20:10400512
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=H8kmjKdi8r" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=H8kmjKdi8r</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/1354750X.2019.1690047" target="_blank" >10.1080/1354750X.2019.1690047</a>
Alternative languages
Result language
angličtina
Original language name
Is Engrailed-2 (EN2) a truly promising biomarker in prostate cancer detection?
Original language description
Purpose: Prostate-specific antigen (PSA) is a sensitive but unspecific marker for prostate cancer (PC) detection, which may result in harms including overdiagnosis and overtreatment. Therefore, the development of new markers is of absolute value. The urinary level of engrailed-2 (EN2) protein has been recently suggested as a promising PC biomarker, correlating with tumour volume and stage. This study evaluated EN2 and its potential use in clinical practice. Materials and methods: Urinary EN2 was assessed by different commercially available enzyme-linked immunosorbent assay kits. The study sample included 90 patients with clinically localized PC compared to 30 healthy controls, and a group of 40 patients indicated for prostate biopsy due to an elevated PSA level where both pre- and post-digital rectal examination urine samples were collected. Results: No statistical difference between the patient group and the control group was obtained in all measured variables. There was no significant correlation between urinary EN2 and serum PSA, tumour staging and grading. Attentive DRE did not lead to significant changes of urinary EN2 or impact on its predictive power. Conclusions: Our results show that EN2 as a PC biomarker brings no additional value to the current use of PSA in clinical practice.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30217 - Urology and nephrology
Result continuities
Project
<a href="/en/project/NV15-33910A" target="_blank" >NV15-33910A: Laboratory and clinical testing of candidate markers for prostate cancer using samples from a complex cryobank of patients with long-term follow-up.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomarkers
ISSN
1354-750X
e-ISSN
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Volume of the periodical
25
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
34-39
UT code for WoS article
000496377900001
EID of the result in the Scopus database
2-s2.0-85075180860