Integrated Molecular and Clinical Analysis of 1,000 Pediatric Low-Grade Gliomas

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10410749" target="_blank" >RIV/00216208:11130/20:10410749 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/20:10410749

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=msLGXoc0dm" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=msLGXoc0dm</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ccell.2020.03.011" target="_blank" >10.1016/j.ccell.2020.03.011</a>

Result language

angličtina

Original language name

Integrated Molecular and Clinical Analysis of 1,000 Pediatric Low-Grade Gliomas

Original language description

Pediatric low-grade gliomas (pLGG) are frequently driven by genetic alterations in the RAS-mitogen-activated protein kinase (RAS/MAPK) pathway yet show unexplained variability in their clinical outcome. To address this, we characterized a cohort of &gt;1,000 clinically annotated pLGG. Eighty-four percent of cases harbored a driver alteration, while those without an identified alteration also often exhibited upregulation of the RAS/MAPK pathway. pLGG could be broadly classified based on their alteration type. Rearrangement-driven tumors were diagnosed at a younger age, enriched for WHO grade I histology, infrequently progressed, and rarely resulted in death as compared with SNV-driven tumors. Further sub-classification of clinical-molecular correlates stratified pLGG into risk categories. These data highlight the biological and clinical differences between pLGG subtypes and opens avenues for future treatment refinement.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancer Cell

ISSN

1535-6108

e-ISSN

—

Volume of the periodical

37

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

15

Pages from-to

569-583

UT code for WoS article

000526112000015

EID of the result in the Scopus database

2-s2.0-85082748299