Exhausted phenotype of follicular CD8 T cells in CVID

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10410932" target="_blank" >RIV/00216208:11130/20:10410932 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/20:10410932
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=8Bsd1OQXwp" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=8Bsd1OQXwp</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jaci.2020.02.025" target="_blank" >10.1016/j.jaci.2020.02.025</a>

Result language
angličtina
Original language name
Exhausted phenotype of follicular CD8 T cells in CVID
Original language description
A unique subset of CD8 T cells has been recently observed in germinal centers (GCs), a location traditionally associated with CD4 T-B interaction and humoral immune response. These follicular CD8 (fCD8) T cells appear to play a role in controlling chronic viral infections such as lymphocytic choriomeningitis virus, hepatitis B, or HIV and are expanded in malignant lymphoproliferation, but their role may be more diverse, as illustrated by their involvement in promoting antibody class switch in mice with autoimmune disease. Susceptibility to viral and bacterial infections, lymphoproliferation, cancer, and autoimmunity are complications seen in most patients with common variable immunodeficiency (CVID), the most prevalent symptomatic primary immunodeficiency with the hallmark of impaired GC-derived specific antibody responses. Our group has previously described an increased prevalence of CD8+ cells in the GCs of patients with CVID and lymphadenopathy. Given the recent emergence of fCD8 T cells as important players in lymphoproliferation and regulation of the GC reaction, we investigated these cells in greater detail using methods described in this article's Online Repository at www.jacionline.org.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30102 - Immunology

Project
<a href="/en/project/NV18-05-00162" target="_blank" >NV18-05-00162: Modern approach to the field of primary immunodeficiencies: translating precise molecular and functional diagnosis to therapy</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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