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Seroprevalence of Borrelia IgM and IgG Antibodies in Healthy Individuals: A Caution Against Serology Misinterpretations and Unnecessary Antibiotic Treatments

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10411072" target="_blank" >RIV/00216208:11130/20:10411072 - isvavai.cz</a>

  • Alternative codes found

    RIV/00064203:_____/20:10411072

  • Result on the web

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ArZZDs1X1s" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ArZZDs1X1s</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1089/vbz.2020.2632" target="_blank" >10.1089/vbz.2020.2632</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Seroprevalence of Borrelia IgM and IgG Antibodies in Healthy Individuals: A Caution Against Serology Misinterpretations and Unnecessary Antibiotic Treatments

  • Original language description

    In Lyme disease, the interpretation of diagnostic assays is often misunderstood. Cross-reactions of Borrelia proteins with antigens from other bacterial species are well known. Therefore, to diagnose Lyme disease, the finding of positive IgM antibodies must be accompanied by objectively verified clinical signs and a history of a possible tick exposure. Positive Borrelia IgM antibodies in healthy individuals with nonspecific clinical symptoms are likely a false-positive result for Lyme disease and neither long-term antibiotic treatment nor cycling of different antibiotic regimens is beneficial. To date, there is clear evidence that positive serology does not indicate infection with Borrelia species. Borrelia serology has been reported to be positive for months or years in similar to 20% of healthy patients who had experienced Lyme disease in the past. Thus, serology as a single diagnostic tool has a very limited value and should be used only to support clinically suspected cases.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30102 - Immunology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Vector-Borne and Zoonotic Diseases

  • ISSN

    1530-3667

  • e-ISSN

  • Volume of the periodical

    20

  • Issue of the periodical within the volume

    10

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    3

  • Pages from-to

    800-802

  • UT code for WoS article

    000532241200001

  • EID of the result in the Scopus database

    2-s2.0-85092680719