Comparison of One-Year Outcomes in Patients >75 Versus <=75 Years With Coronary Artery Disease Treated With COMBO Stents (From The MASCOT Registry)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10411273" target="_blank" >RIV/00216208:11130/20:10411273 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/20:00072836 RIV/00064203:_____/20:10411273 RIV/00023884:_____/20:00008678

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=4uTwDsQi3A" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=4uTwDsQi3A</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.amjcard.2020.04.014" target="_blank" >10.1016/j.amjcard.2020.04.014</a>

Result language

angličtina

Original language name

Comparison of One-Year Outcomes in Patients >75 Versus <=75 Years With Coronary Artery Disease Treated With COMBO Stents (From The MASCOT Registry)

Original language description

Older patients who undergo coronary interventions are at greater risk of ischemic events and less likely to tolerate prolonged dual antiplatelet therapy (DAPT) due to bleeding risk. The COMBO biodegradable polymer sirolimus-eluting stent promotes rapid endothelialization through endothelial progenitor cell capture technology which may be advantageous in elderly patients. We compared 1-year clinical outcomes and DAPT cessation events in patients &gt;75 versus &lt;=75 years from the MASCOT registry. MASCOT was a prospective, multicenter cohort study of all-comers undergoing attempted COMBO stenting. The primary endpoint was 1-year target lesion failure (TLF), composite of cardiac death, myocardial infarction (MI) not clearly attributed to a nontarget vessel or clinically driven target lesion revascularization. Bleeding was adjudicated using the Bleeding Academic Research Consortium criteria. Adjusted outcomes were analyzed using Cox regression methods. The study included 18% (n = 479) patients &gt;75 years and 72% (n = 2,135) patients &lt;=75 years. One-year TLF occurred in 4.6% patients &gt;75 years versus 3.1% patients &lt;=75years of age, p = 0.10; adj hazard ratio 1.36, 95% confidence intervals 0.77 to 2.38, p = 0.29. There were no significant differences in cardiac death (1.7% vs 1.3%, p = 0.55), MI (2.1% vs 1.2%, p = 0.14), target lesion revascularization (1.7% vs 1.4%, p = 0.60) and definite stent thrombosis (0.8% vs 0.4%, p = 0.19). Major Bleeding Academic Research Consortium 3,5 bleeding (3.1% vs 1.5%, p = 0.01) and DAPT cessation rates (32.4% vs 23.0%, p &lt;0.001) were significantly higher in elderly patients. In conclusion, elderly patients &gt;75 years treated with COMBO stents had similar TLF but significantly greater incidence of bleeding than younger patients and DAPT cessation in one-third of patients over 1 year. (C) 2020

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

The American Journal of Cardiology

ISSN

0002-9149

e-ISSN

—

Volume of the periodical

127

Issue of the periodical within the volume

July

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

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UT code for WoS article

000542275400001

EID of the result in the Scopus database

2-s2.0-85085136938