'Gentamicin 240 mg plus azithromycin 2 g vs. ceftriaxone 500 mg plus azithromycin 2 g for treatment of rectal and pharyngeal gonorrhoea' - Author's reply
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10411849" target="_blank" >RIV/00216208:11130/20:10411849 - isvavai.cz</a>
Alternative codes found
RIV/00064211:_____/20:W0000024
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=1_fZ_Bk459" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=1_fZ_Bk459</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cmi.2020.02.033" target="_blank" >10.1016/j.cmi.2020.02.033</a>
Alternative languages
Result language
angličtina
Original language name
'Gentamicin 240 mg plus azithromycin 2 g vs. ceftriaxone 500 mg plus azithromycin 2 g for treatment of rectal and pharyngeal gonorrhoea' - Author's reply
Original language description
We are grateful to Dr Sfeir for the insightful comments on our paper. We completely agree that a major limitation with Neisseria gonorrhoeae nucleic acid amplification tests (NAATs) is the lack of complete antimicrobial resistance (AMR) data, which only gonococcal culture can offer. However, in studies focusing on examination of rectal and pharyngeal specimens (as in our study), a gonococcal NAAT for diagnosis is essential due to the exceedingly low sensitivity using culture:: i.e., ideally both NAAT and culture should be used for all specimens, but this is not always cost-effective or feasible. This strongly emphasizes the importance of developing appropriate rapid molecular assays to predict gonococcal AMR, which ideally could detect N. gonorrhoeae and multiple AMR determinants, and could be used at the point of care. Such assays could be used for diagnosis of gonorrhoea, to inform individualized treatment (sparing the last line of empirical treatment), and for AMR surveillance.
Czech name
—
Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10606 - Microbiology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Microbiology and Infection
ISSN
1198-743X
e-ISSN
—
Volume of the periodical
26
Issue of the periodical within the volume
6
Country of publishing house
GB - UNITED KINGDOM
Number of pages
2
Pages from-to
799-800
UT code for WoS article
000536144300033
EID of the result in the Scopus database
2-s2.0-85085006605