Subsequent neoplasms in childhood cancer survivors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10412667" target="_blank" >RIV/00216208:11130/20:10412667 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/20:10412667
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=I2Y8Os8j8S" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=I2Y8Os8j8S</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.canep.2020.101779" target="_blank" >10.1016/j.canep.2020.101779</a>
Alternative languages
Result language
angličtina
Original language name
Subsequent neoplasms in childhood cancer survivors
Original language description
Objectives: The aim of the study was to characterize subsequent neoplasm (SN) (malignant (SMN), benign (BSNs), and non-melanoma skin cancer (NMSC)) treated previously for a childhood solid malignant tumor at the Department of Pediatric Hematology and Oncology, Motol University Hospital, Prague. Method: We evaluated a cohort of 4059 childhood cancer survivors treated between 1975 and 2018. Results: From 4059 survivors, 170 (4.3 %) developed at least one SMN - 193 SMNs in 170 survivors, 21 of them (0.5 % of all survivors) had two or more SMNs and 34 of them (0.8 %) had one SMN and one or more BSNs. Mortality for an SMN was 38.2 % i.e. 1.6 % of all survivors. The most frequent SMNs were thyroid carcinoma (37, 19.2 %), tumors of the central nervous system (25, 13.0 %), soft tissue sarcoma (23, 11.9 %), breast carcinoma (19, 9.8 %), and leukemia (11, 5.7 %). Genetic syndromes were present in 25 patients with SMNs (14.7 %) and in 16 patients with only BSNs (13.4 %). SMNs usually developed in second decade or later after finishing of therapy. We observed some not well known risk factors of SNs e.g. spinal irradiation or131-I metaiodobenzylguanidine radiotherapy in 2 cases of secondary thyroid cancer, cyclophosphamide therapy in all 8 cases of secondary urinary bladder sarcoma or 4 from 7 SNMSC developed SMN. Conclusions: We confirmed data from previous studies of SNs and observed some not so well known risk factors. Our results and the literature show that the incidence of SMNs is 3-10 % of survivors and is associated with high mortality.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
<a href="/en/project/NV19-03-00245" target="_blank" >NV19-03-00245: Signs of accelerated aging as late effect of therapy for childhood cancer and as risk factor of subsequent malignant neoplasms.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cancer Epidemiology
ISSN
1877-7821
e-ISSN
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Volume of the periodical
68
Issue of the periodical within the volume
October
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
101779
UT code for WoS article
000575396200007
EID of the result in the Scopus database
2-s2.0-85087939927