PCL scaffold for osteochondral defect treatment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10412733" target="_blank" >RIV/00216208:11130/20:10412733 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/20:00577507
Result on the web
<a href="https://doi.org/10.4028/www.scientific.net/KEM.834.141" target="_blank" >https://doi.org/10.4028/www.scientific.net/KEM.834.141</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4028/www.scientific.net/KEM.834.141" target="_blank" >10.4028/www.scientific.net/KEM.834.141</a>
Alternative languages
Result language
angličtina
Original language name
PCL scaffold for osteochondral defect treatment
Original language description
Osteochondral defects develop as a result of trauma, microtrauma, avascular necrosis or cancer. These are usually pre-arthrotic conditions, accompanied by chronic pain and limited joint mobility leading to decreased quality of life of the affected patients. The bone itself has self-repair potential facilitated by mesenchymal stem cells and other cells present in the bone tissue. On the other hand, mature cartilage has very low regenerative capacity due to limited mitotic potential of chondrocytes and lack of vascularization. Therefore, there is an effort to develop an alternative treatment strategy supporting and accelerating natural healing processes. We have designed nanofibrous scaffolds made of poly-ε-caprolactone/hyaluronic acid and enriched with specific growth factors - "osteogenic" part with BMP-2 and "chondrogenic" part with bFGF and TGF-β. These two parts are meant to be combined in one biphasic non-cellular scaffold which would be possible to implant in the site of injury and serve as a mechanical support for the cells. We examined proliferation and viability of cells, depth of their penetration into scaffold, cell distribution, alkaline phosphatase activity and extracellular matrix proteins expression. We showed both "osteogenic" and "chondrogenic" scaffold was suitable for cell growth. Moreover, in comparison to the control samples, these two scaffolds exhibited positive effect on chondrogenic and osteogenic differentiation, respectively.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
10610 - Biophysics
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Key Engineering Materials
ISBN
978-3-0357-1519-4
Number of pages of the result
7
Pages from-to
141-147
Number of pages of the book
182
Publisher name
Trans Tech Publications Ltd
Place of publication
Švýcarsko
UT code for WoS chapter
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