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PCL scaffold for osteochondral defect treatment

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10412733" target="_blank" >RIV/00216208:11130/20:10412733 - isvavai.cz</a>

  • Alternative codes found

    RIV/68378041:_____/20:00577507

  • Result on the web

    <a href="https://doi.org/10.4028/www.scientific.net/KEM.834.141" target="_blank" >https://doi.org/10.4028/www.scientific.net/KEM.834.141</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.4028/www.scientific.net/KEM.834.141" target="_blank" >10.4028/www.scientific.net/KEM.834.141</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    PCL scaffold for osteochondral defect treatment

  • Original language description

    Osteochondral defects develop as a result of trauma, microtrauma, avascular necrosis or cancer. These are usually pre-arthrotic conditions, accompanied by chronic pain and limited joint mobility leading to decreased quality of life of the affected patients. The bone itself has self-repair potential facilitated by mesenchymal stem cells and other cells present in the bone tissue. On the other hand, mature cartilage has very low regenerative capacity due to limited mitotic potential of chondrocytes and lack of vascularization. Therefore, there is an effort to develop an alternative treatment strategy supporting and accelerating natural healing processes. We have designed nanofibrous scaffolds made of poly-ε-caprolactone/hyaluronic acid and enriched with specific growth factors - &quot;osteogenic&quot; part with BMP-2 and &quot;chondrogenic&quot; part with bFGF and TGF-β. These two parts are meant to be combined in one biphasic non-cellular scaffold which would be possible to implant in the site of injury and serve as a mechanical support for the cells. We examined proliferation and viability of cells, depth of their penetration into scaffold, cell distribution, alkaline phosphatase activity and extracellular matrix proteins expression. We showed both &quot;osteogenic&quot; and &quot;chondrogenic&quot; scaffold was suitable for cell growth. Moreover, in comparison to the control samples, these two scaffolds exhibited positive effect on chondrogenic and osteogenic differentiation, respectively.

  • Czech name

  • Czech description

Classification

  • Type

    C - Chapter in a specialist book

  • CEP classification

  • OECD FORD branch

    10610 - Biophysics

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Book/collection name

    Key Engineering Materials

  • ISBN

    978-3-0357-1519-4

  • Number of pages of the result

    7

  • Pages from-to

    141-147

  • Number of pages of the book

    182

  • Publisher name

    Trans Tech Publications Ltd

  • Place of publication

    Švýcarsko

  • UT code for WoS chapter