Growth databases and registries - towards understanding physiological effects of growth hormone

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10415812" target="_blank" >RIV/00216208:11130/20:10415812 - isvavai.cz</a>

Alternative codes found

RIV/00064203:_____/20:10415812

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=e2qfsTeMwe" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=e2qfsTeMwe</a>

DOI - Digital Object Identifier

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Result language

čeština

Original language name

Růstové databáze a registry - cesta k poznání fyziologických účinků růstového hormonu

Original language description

Growth hormone (GH) has been used as a drug since 1956. Since mid-1980s, recombinant human growth hormone has been available for the treatment. The recombinant production of GH has contributed to extending the indication of treatment and significantly increasing the number of treated patients. In the past 35 years, growth databases and registers have been used to monitor the physiological effects of growth hormone treatment in routine practice by collecting clinical data about treated patients. The first and most extensive KIGS database contains data about more than 83,000 children. Based on this database, robust mathematical models have been developed, which are predicting the effects of growth hormone treatment. The GeNeSIS database contains more than 22,000 children. Simultaneously it contributed to understanding the genetic etiology of growth hormone deficiency and to assessing the potential risks of therapy. Nordinet(R) IOS has data on nearly 18,000 children. The last, smallest, but unique is the ECOS database, which, thanks to the web-based data collection about each injection, provide to assess the adherence and compliance of patients and their impact on the effect of therapy. Growth databases and registers helped to understand the algorithms of growth hormone treatment, also contributed to its optimization and particularly to more effective use of financial means for the treatment.

Czech name

Růstové databáze a registry - cesta k poznání fyziologických účinků růstového hormonu

Czech description

Growth hormone (GH) has been used as a drug since 1956. Since mid-1980s, recombinant human growth hormone has been available for the treatment. The recombinant production of GH has contributed to extending the indication of treatment and significantly increasing the number of treated patients. In the past 35 years, growth databases and registers have been used to monitor the physiological effects of growth hormone treatment in routine practice by collecting clinical data about treated patients. The first and most extensive KIGS database contains data about more than 83,000 children. Based on this database, robust mathematical models have been developed, which are predicting the effects of growth hormone treatment. The GeNeSIS database contains more than 22,000 children. Simultaneously it contributed to understanding the genetic etiology of growth hormone deficiency and to assessing the potential risks of therapy. Nordinet(R) IOS has data on nearly 18,000 children. The last, smallest, but unique is the ECOS database, which, thanks to the web-based data collection about each injection, provide to assess the adherence and compliance of patients and their impact on the effect of therapy. Growth databases and registers helped to understand the algorithms of growth hormone treatment, also contributed to its optimization and particularly to more effective use of financial means for the treatment.

Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

30209 - Paediatrics

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Česko-slovenská pediatrie

ISSN

0069-2328

e-ISSN

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Volume of the periodical

75

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

251-255

UT code for WoS article

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EID of the result in the Scopus database

2-s2.0-85090641489