Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10416589" target="_blank" >RIV/00216208:11130/20:10416589 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/20:10416589
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=iXM5wDF_" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=iXM5wDF_</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1126/sciadv.aba2578" target="_blank" >10.1126/sciadv.aba2578</a>
Alternative languages
Result language
angličtina
Original language name
Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children
Original language description
As the incidence of immune-mediated diseases has increased rapidly in developed societies, there is an unmet need for novel prophylactic practices to fight against these maladies. This study is the first human intervention trial in which urban environmental biodiversity was manipulated to examine its effects on the commensal microbiome and immunoregulation in children. We analyzed changes in the skin and gut microbiota and blood immune markers of children during a 28-day biodiversity intervention. Children in standard urban and nature-oriented daycare centers were analyzed for comparison. The intervention diversified both the environmental and skin Gammaproteobacterial communities, which, in turn, were associated with increases in plasma TGF-β1 levels and the proportion of regulatory T cells. The plasma IL-10:IL-17A ratio increased among intervention children during the trial. Our findings suggest that biodiversity intervention enhances immunoregulatory pathways and provide an incentive for future prophylactic approaches to reduce the risk of immune-mediated diseases in urban societies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30209 - Paediatrics
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Science advances [online]
ISSN
2375-2548
e-ISSN
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Volume of the periodical
6
Issue of the periodical within the volume
42
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
eaba2578
UT code for WoS article
000579164600007
EID of the result in the Scopus database
2-s2.0-85093484467