Tissue engineering and regenerative medicine in spinal cord injury repair
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10441268" target="_blank" >RIV/00216208:11130/20:10441268 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/B978-0-12-818084-6.00008-8" target="_blank" >https://doi.org/10.1016/B978-0-12-818084-6.00008-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/B978-0-12-818084-6.00008-8" target="_blank" >10.1016/B978-0-12-818084-6.00008-8</a>
Alternative languages
Result language
angličtina
Original language name
Tissue engineering and regenerative medicine in spinal cord injury repair
Original language description
Spinal cord injury (SCI) is a devastating trauma that often leads to a permanent loss of motor and sensory functions, pain, and spasticity. A functional repair of injured tissue in the adult central nervous system remains a major issue for current biomedical research and its advancing clinical translation. Regenerative medicine, together with tissue engineering and various interdisciplinary methods, may offer new approaches to reduce neuronal death, glial scars at the injury site, and induce axonal regeneration. In this review we introduce SCI, its pathophysiology, available experimental models, and behavioral testing, which have been used for its further study. We also provide a comprehensive overview of selected experimental approaches based on cell transplantation, antioxidative treatment, laser therapy, biomaterial scaffolds, and their combinations. Finally, we consider the future direction of spinal neuromodulation research such as electrical stimulation or molecular manipulation, which could overcome molecular barriers inhibiting axonal growth to promote regeneration.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Handbook of Innovations in Central Nervous System Regenerative Medicine
ISBN
978-0-12-818084-6
Number of pages of the result
42
Pages from-to
291-332
Number of pages of the book
686
Publisher name
Elsevier
Place of publication
Amsterdam
UT code for WoS chapter
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