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Tissue engineering and regenerative medicine in spinal cord injury repair

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10441268" target="_blank" >RIV/00216208:11130/20:10441268 - isvavai.cz</a>

  • Result on the web

    <a href="https://doi.org/10.1016/B978-0-12-818084-6.00008-8" target="_blank" >https://doi.org/10.1016/B978-0-12-818084-6.00008-8</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/B978-0-12-818084-6.00008-8" target="_blank" >10.1016/B978-0-12-818084-6.00008-8</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Tissue engineering and regenerative medicine in spinal cord injury repair

  • Original language description

    Spinal cord injury (SCI) is a devastating trauma that often leads to a permanent loss of motor and sensory functions, pain, and spasticity. A functional repair of injured tissue in the adult central nervous system remains a major issue for current biomedical research and its advancing clinical translation. Regenerative medicine, together with tissue engineering and various interdisciplinary methods, may offer new approaches to reduce neuronal death, glial scars at the injury site, and induce axonal regeneration. In this review we introduce SCI, its pathophysiology, available experimental models, and behavioral testing, which have been used for its further study. We also provide a comprehensive overview of selected experimental approaches based on cell transplantation, antioxidative treatment, laser therapy, biomaterial scaffolds, and their combinations. Finally, we consider the future direction of spinal neuromodulation research such as electrical stimulation or molecular manipulation, which could overcome molecular barriers inhibiting axonal growth to promote regeneration.

  • Czech name

  • Czech description

Classification

  • Type

    C - Chapter in a specialist book

  • CEP classification

  • OECD FORD branch

    30103 - Neurosciences (including psychophysiology)

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Book/collection name

    Handbook of Innovations in Central Nervous System Regenerative Medicine

  • ISBN

    978-0-12-818084-6

  • Number of pages of the result

    42

  • Pages from-to

    291-332

  • Number of pages of the book

    686

  • Publisher name

    Elsevier

  • Place of publication

    Amsterdam

  • UT code for WoS chapter