Novel Paradigm of Subdural Cortical Stimulation Does Not Cause Thermal Damage in Brain Tissue: A Simulation-Based Study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F21%3A10419164" target="_blank" >RIV/00216208:11130/21:10419164 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21230/21:00344456 RIV/68407700:21460/21:00344456 RIV/00064203:_____/21:10419164
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=lvpofmM4Nl" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=lvpofmM4Nl</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1109/TNSRE.2020.3043823" target="_blank" >10.1109/TNSRE.2020.3043823</a>
Alternative languages
Result language
angličtina
Original language name
Novel Paradigm of Subdural Cortical Stimulation Does Not Cause Thermal Damage in Brain Tissue: A Simulation-Based Study
Original language description
The thermal effect of a novel effective electrical stimulation mapping (ESM) technique using an Ojemann's stimulation electrode in open craniotomy areas causes a nondestructive local increase in temperature. Another type of stimulating electrode is a subdural strip, routinely used in intraoperative electrocorticography (ECoG), which applies ESM in a covered subdural area over the motor cortex. ECoG electrode geometry produces a different electrical field, causing a different Joule heat distribution in tissue, one that is impossible to measure in subdural space. Therefore, the previous safety control study of the novel ESM technique needed to be extended to include an assessment of the thermal effect of ECoG strip electrodes. We adapted a previously well-validated numerical model and performed coupled complex electro-thermal transient simulations for short-time (28.4 ms) high-frequency (500 Hz) and hyperintense (peak 100 mA) ESM paradigm. The risk of heat-induced cellular damage was assessed by applying the Arrhenius equation integral on the computed time-dependent spatial distribution of temperature in the brain tissue during ESM stimulation and during the cooldown period. The results showed increases in temperature in the proximity around ECoG electrode discs in a safe range without destructive effects. As opposed to open craniotomy, subdural space is not cooled by the air; hence a higher - but still safe - induced temperature was observed. The presented simulation agrees with the previously published histopathological examination of the stimulated brain tissue, and confirms the safety of the novel ESM technique when applied using ECoG strip electrodes.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
IEEE Transactions on Neural Systems and Rehabilitation Engineering
ISSN
1534-4320
e-ISSN
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Volume of the periodical
29
Issue of the periodical within the volume
December
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
230-238
UT code for WoS article
000626331500003
EID of the result in the Scopus database
2-s2.0-85097956747