Pancreatitis-associated protein as an early marker of asparaginase-associated pancreatitis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F21%3A10429926" target="_blank" >RIV/00216208:11130/21:10429926 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/21:10429926
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=NbM_xicM6b" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=NbM_xicM6b</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/10428194.2021.1961236" target="_blank" >10.1080/10428194.2021.1961236</a>

Result language
angličtina
Original language name
Pancreatitis-associated protein as an early marker of asparaginase-associated pancreatitis
Original language description
Our study represents the first description of PAP, a novel early marker for AAP risk prediction, in pediatric patients with ALL and AAP, detection of which could potentially lead to individual patient therapy tailoring. By identifying patients susceptible to AAP and avoiding its severe manifestations, L-asparaginase truncation could be eschewed, which could eventually result in an improvement of patients' overall outcome. We propose that patients with elevated PAP levels should be closely monitored for possible AAP development. Frequent measurements of PAP and AAP diagnostic markers should be exploited, predominantly in treatment protocols with serial L-asparaginase administrations, together with the early use of imaging methods when clinical symptoms appear. Last but not least, we believe that the presented data will stimulate additional larger studies addressing this important question.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30205 - Hematology

Project
<a href="/en/project/NV18-07-00129" target="_blank" >NV18-07-00129: Role of leukemia cell metabolism in disease manifestation, progression and therapy response</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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