Autophagic processes in early- and late-onset Alzheimer's disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F21%3A10442107" target="_blank" >RIV/00216208:11130/21:10442107 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/21:10442107
Result on the web
<a href="https://doi.org/10.1016/B978-0-12-822003-0.00012-7" target="_blank" >https://doi.org/10.1016/B978-0-12-822003-0.00012-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/B978-0-12-822003-0.00012-7" target="_blank" >10.1016/B978-0-12-822003-0.00012-7</a>
Alternative languages
Result language
angličtina
Original language name
Autophagic processes in early- and late-onset Alzheimer's disease
Original language description
Autophagy plays a fundamental role in maintaining intracellular homeostasis and cell survival by degrading damaged and unnecessary subcellular components via the lysosome. Impaired autophagy is evident in otherwise "normal" elderly individuals and patients with neurodegenerative diseases, such as Alzheimer's disease (AD). As the most common type of dementia, AD is an age-associated disease with memory loss as the primary clinical feature as well as extracellular Aβ plaques and intracellular Tau tangles as disease-defining pathological features. Recent studies in animal models of AD, AD patient-derived stem cells, and AD postmortem brain tissues suggest that compromised mitophagy/autophagy plays a causative role in AD progression. Supporting this hypothesis, pharmacological approaches to induce mitophagy/autophagy-e.g., the use of the small natural molecule oxidized nicotinamide adenine dinucleotide (NAD+)-slow AD progression in animal models. This chapter reviews the extant literature on autophagy in AD and covers recent progress on the molecular mechanisms of NAD+-dependent mitophagy/autophagy regulation and mechanisms underlying the anti-AD potential of NAD+. Further studies to define the NAD+-mitophagy/autophagy axis may shed light on novel therapeutics to treat AD and potentially provide insights into other neurodegenerative diseases.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
—
OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/TO01000215" target="_blank" >TO01000215: Validation of specific mitophagy biomarkers across Alzheimer's disease continuum</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Autophagy in Health and Disease
ISBN
978-0-12-822003-0
Number of pages of the result
13
Pages from-to
287-299
Number of pages of the book
454
Publisher name
Elsevier, Academic Press
Place of publication
London
UT code for WoS chapter
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