Hemodynamics During Development and Postnatal Life
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F24%3A10481411" target="_blank" >RIV/00216208:11130/24:10481411 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/24:10481411 RIV/00064203:_____/24:10481411
Result on the web
<a href="https://doi.org/10.1007/978-3-031-44087-8_11" target="_blank" >https://doi.org/10.1007/978-3-031-44087-8_11</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-031-44087-8_11" target="_blank" >10.1007/978-3-031-44087-8_11</a>
Alternative languages
Result language
angličtina
Original language name
Hemodynamics During Development and Postnatal Life
Original language description
A well-developed heart is essential for embryonic survival. There are constant interactions between cardiac tissue motion and blood flow, which determine the heart shape itself. Hemodynamic forces are a powerful stimulus for cardiac growth and differentiation. Therefore, it is particularly interesting to investigate how the blood flows through the heart and how hemodynamics is linked to a particular species and its development, including human. The appropriate patterns and magnitude of hemodynamic stresses are necessary for the proper formation of cardiac structures, and hemodynamic perturbations have been found to cause malformations via identifiable mechanobiological molecular pathways. There are significant differences in cardiac hemodynamics among vertebrate species, which go hand in hand with the presence of specific anatomical structures. However, strong similarities during development suggest a common pattern for cardiac hemodynamics in human adults. In the human fetal heart, hemodynamic abnormalities during gestation are known to progress to congenital heart malformations by birth. In this chapter, we discuss the current state of the knowledge of the prenatal cardiac hemodynamics, as discovered through small and large animal models, as well as from clinical investigations, with parallels gathered from the poikilotherm vertebrates that emulate some hemodynamically significant human congenital heart diseases.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Congenital Heart Diseases: The Broken Heart
ISBN
978-3-031-44086-1
Number of pages of the result
26
Pages from-to
201-226
Number of pages of the book
1112
Publisher name
Springer
Place of publication
Cham
UT code for WoS chapter
001283543300013