Mesenchymal Stem Cells Attenuate Renal Microscopic Alterations in Induced Diabetic Nephropathy in Rats through Suppression of Oxidative Stress, Inflammation, Apoptosis and Upregulation of Nrf2/PPAR-γ Inflammatory Signaling Pathway
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F25%3A10496732" target="_blank" >RIV/00216208:11130/25:10496732 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=64UQhsXJ3I" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=64UQhsXJ3I</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4067/S0717-95022025000100226" target="_blank" >10.4067/S0717-95022025000100226</a>
Alternative languages
Result language
angličtina
Original language name
Mesenchymal Stem Cells Attenuate Renal Microscopic Alterations in Induced Diabetic Nephropathy in Rats through Suppression of Oxidative Stress, Inflammation, Apoptosis and Upregulation of Nrf2/PPAR-γ Inflammatory Signaling Pathway
Original language description
Diabetic nephropathy (DN) is a prevalent complication of diabetes, necessitating the development of effective therapies targeting the mechanisms by which type 2 diabetes mellitus (T2DM) induces renal tissue damage. In this study, DN was induced in rats using a high-fat diet for 13 weeks combined with streptozotocin to assess the effects of mesenchymal stem(MSCs) cells injection on renal tissues and function. Histological, immunohistochemistry, and biochemical analysis were employed to evaluate inflammation, oxidative stress, apoptosis, and histological architecture. The results demonstrated that MSCs improved metabolic derangement (glucose and lipid profile) and kidney function (urea and creatinine) associated with a significant reduction inflammatoryin biomarkers: high sensitivity CRP (hs-CRP), tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), as well as oxidative stress biomarkers :reactive: oxygen species (ROS) and superoxide dismutase (SOD). Additionally, MSCs administration upregulates omeperoxi proliferator-activated receptor gamma (PPAR gamma) and nuclear factor erythroid 2-related factor 2 (Nrf2) expression levels. MSCs also show improved histological architecture associated with decreased CD45 (marker of inflammation) and caspase-3 (marker of apoptosis) immunostaining in renal tissues of the treated diabetic group. In conclusion, MSCs improved diabetic-induced nephropathyh throug suppression of oxidative stress, inflammation, apoptosis and upregulation of the Nrf2/PPAR-gamma inflammatory signaling pathway.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30106 - Anatomy and morphology (plant science to be 1.6)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Morphology
ISSN
0717-9367
e-ISSN
0717-9502
Volume of the periodical
43
Issue of the periodical within the volume
1
Country of publishing house
CL - CHILE
Number of pages
11
Pages from-to
226-236
UT code for WoS article
001450583300030
EID of the result in the Scopus database
2-s2.0-105001432960