Mixtures of chemicals in pregnancy and their effects on cognitive and fine motor abilities in childhood

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F25%3A10499813" target="_blank" >RIV/00216208:11130/25:10499813 - isvavai.cz</a>

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=hfJpNEJzsf" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=hfJpNEJzsf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.envres.2025.122380" target="_blank" >10.1016/j.envres.2025.122380</a>

Result language

angličtina

Original language name

Mixtures of chemicals in pregnancy and their effects on cognitive and fine motor abilities in childhood

Original language description

This study evaluates effects of a mixture of 29 chemicals in pregnancy (organochlorine compounds, per - and polyfluoroalkyl substances, phenols, and phthalates) on cognitive abilities (working memory, attentional function, visuomotor attention, cognitive flexibility, verbal and non-verbal intelligence, information processing speed, risky decision making) and fine motor function in childhood. Data from over 2000 mothers and their children that take part in the INfancia y Medio Ambiente in Spain were analyzed. Quantile-based g-computation estimated joint effects of chemical mixtures on the outcomes, adjusting for confounders and using inverse probability weights to mitigate selection bias. The overall mixture of chemicals was linked to lower visuomotor attention (+ 0.2 min., 95 % CI 0.0 to 0.4 for the second; + 0.4 min., 95 % CI 0.0 to 0.8 for the third; and + 0.7 min., 95 % CI 0.0 to 1.3 for the fourth quartile, relative to the first quartile). Counterintuitively, the overall mixture of chemicals was related to higher verbal intelligence (+ 1.5 points, 95 % CI 0.1 to 3.0 for the second; + 3.0 points, 95 % CI 0.1 to 6.0 for the third; and + 4.6 points, 95 % CI 0.2 to 9.0 for the fourth quartile, relative to the first quartile). However, neither of these associations survived multiple testing correction. Our study does not provide strong evidence that prenatal exposure to a mixture of organochlorine compounds, per - and polyfluoroalkyl substances, phenols, and phthalates affects cognitive abilities or fine motor function in childhood.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30304 - Public and environmental health

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Environmental Research

ISSN

0013-9351

e-ISSN

1096-0953

Volume of the periodical

285

Issue of the periodical within the volume

Part 2

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

122380

UT code for WoS article

001545453100012

EID of the result in the Scopus database

2-s2.0-105011859521