Valganciclovir prophylaxis against cytomegalovirus impairs lymphocyte proliferation and activation in renal transplant recipients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F11%3A10104743" target="_blank" >RIV/00216208:11140/11:10104743 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.3851/IMP1879" target="_blank" >http://dx.doi.org/10.3851/IMP1879</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3851/IMP1879" target="_blank" >10.3851/IMP1879</a>

Result language

angličtina

Original language name

Valganciclovir prophylaxis against cytomegalovirus impairs lymphocyte proliferation and activation in renal transplant recipients

Original language description

Adult renal transplant recipients were assigned to 3-month prophylaxis with either valganciclovir (900mg q.d., n=19) or valacyclovir (2g q.i.d., n=17) as part of an ongoing randomized trial. Subsets of lymphocytes, lymphocyte proliferation and/or cytokine production after in vitro mitogen stimulation were evaluated at the end of prophylaxis and one month after withdrawal of antiviral drugs. Lymphocyte proliferation was significantly decreased both after phytohemagglutinine (25+-15 vs. 32+-18%, P=0.025)and concanavalin A stimulation (17+-9 vs. 25+-16%, P=0.011) during valganciclovir, but not valacyclovir therapy. Moreover, a lower activated T cell count (CD3+HLA-DR+ cells) was noted in valganciclovir-treated patients (13+-10 vs. 17+-12% of total CD3+ Tcells, P=0.005). Conclusions: Valganciclovir suppresses lymphocyte proliferation and activation in patients after renal transplantation.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FJ - Surgery including transplantology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Antiviral Therapy

ISSN

1359-6535

e-ISSN

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Volume of the periodical

16

Issue of the periodical within the volume

8

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

1227-1235

UT code for WoS article

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EID of the result in the Scopus database

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