High-grade mucinous tubular and spindle cell carcinoma: comparative genomic hybridization study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F11%3A10105755" target="_blank" >RIV/00216208:11140/11:10105755 - isvavai.cz</a>

Alternative codes found

RIV/00669806:_____/11:10105755

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S1092913410001437" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1092913410001437</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.anndiagpath.2010.08.003" target="_blank" >10.1016/j.anndiagpath.2010.08.003</a>

Result language

angličtina

Original language name

High-grade mucinous tubular and spindle cell carcinoma: comparative genomic hybridization study

Original language description

Mucinous tubular and spindle cell carcinoma (MTSCC) has recently been integrated into the World Health Organization classification. Although MTSCC is generally a low-grade carcinoma, MTSCC with high-grade morphology has been recently reported. We presentthe first case of high-grade MTSCC with comparative genomic hybridization findings. A 60-year-old Japanese man presented with weight loss and general fatigue. He underwent radical nephrectomy because of the clinical diagnosis of renal cancer. Histologicexamination of renal tumor showed findings of high-grade MTSCC. Comparative genomic hybridization analysis showed gain of chromosomes 1q, 7, 16, 19q, and Y and loss of chromosomes 1p, 6p, 8p, 11q (del(11)(q23)), and 13. G-band karyotype showed gain of chromosomes 2, 3, 5, 7, 12, 16, and 20 and loss of chromosome 15. Results of our molecular genetic analysis support the idea that high-grade MTSCC is a real counterpart of low-grade MTSCC. There is no evidence to designate such tumors as u

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Annals of Diagnostic Pathology

ISSN

1092-9134

e-ISSN

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Volume of the periodical

15

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

4

Pages from-to

472-475

UT code for WoS article

000297481900018

EID of the result in the Scopus database

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