Re-evaluation of histological type by immunohistochemical and genetic study of transcription factors (TFE3 and TFEB) of VHL gene mutation-negative clear cell renal cell carcinoma and other special types of renal tumor

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F11%3A10105897" target="_blank" >RIV/00216208:11140/11:10105897 - isvavai.cz</a>

Alternative codes found

RIV/00669806:_____/11:10105897

Result on the web

<a href="http://www.springerlink.com/content/q012571553715600/fulltext.pdf" target="_blank" >http://www.springerlink.com/content/q012571553715600/fulltext.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00795-009-0478-3" target="_blank" >10.1007/s00795-009-0478-3</a>

Result language

angličtina

Original language name

Re-evaluation of histological type by immunohistochemical and genetic study of transcription factors (TFE3 and TFEB) of VHL gene mutation-negative clear cell renal cell carcinoma and other special types of renal tumor

Original language description

Translocation-type renal carcinoma has been recently discovered, and it is possible that this tumor may have been previously diagnosed as other types of renal tumor. We have subjected 41 renal tumors, including VHL gene mutation-negative clear cell renalcell carcinoma (RCC), papillary RCC, and chromophobe RCC, to immunohistochemistry of transcription factor E3 (TFE3) and TFEB. All tumors were histologically evaluated by additional immunohistochemical study. As a result, 5 tumors showed a positive reaction for TFE3 with a range from 1+ to 2+ in intensity. No tumors were positive for TFEB. In 5 tumors immunohistochemically positive for TFE3, chimeric transcripts including ASPL-TFE3, PRCC-TFE3, CLTCTFE3, PSF-TFE3, or Nono-TFE3 were not detected. The diagnosis of 6 tumors was changed by reevaluation through retrospective histological and immunohistochemical study. In 4 of 6 tumors, the diagnosis of clear cell RCC was changed to chromophobe RCC. In 1 tumor, oncocytoma was detectable, and R

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Medical Molecular Morphology

ISSN

1860-1480

e-ISSN

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Volume of the periodical

44

Issue of the periodical within the volume

1

Country of publishing house

DE - GERMANY

Number of pages

6

Pages from-to

46-51

UT code for WoS article

000288665300008

EID of the result in the Scopus database

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