Angiogenic markers in canine lymphoma tissues do not predict survival times in chemotherapy treated dogs

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F12%3A10118885" target="_blank" >RIV/00216208:11140/12:10118885 - isvavai.cz</a>
Alternative codes found
RIV/49777513:23520/12:43914887
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0034528811001706" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0034528811001706</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.rvsc.2011.04.018" target="_blank" >10.1016/j.rvsc.2011.04.018</a>

Result language
angličtina
Original language name
Angiogenic markers in canine lymphoma tissues do not predict survival times in chemotherapy treated dogs
Original language description
Angiogenesis, which is essential for malignancies to progress, depends on various signalling proteins including vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptors 1 and 2 (VEGFR-1 and VEGFR-2). Microvessel density(MVD) is frequently used to evaluate angiogenesis. This study assessed the relationship between expression of VEGF, VEGFR-1 and VEGFR-2, MVD and the survival time in dogs with lymphoma. VEGF, VEGFR-1 and VEGFR-2 expression was evaluated immunohistochemically and microvessel profiles were counted in 34 lymphoma samples. Seventy-nine percent of the samples showed high VEGF expression and 62% were highly positive for VEGFR-1; VEGFR-2 immunoreactivity was mostly negative. Dogs treated with chemotherapy hada median survival time of 266days, but no significant relationships were found between overall survival time, MVD and expression of VEGF, VEGFR-1 or VEGFR-2. In this study, VEGF its receptors and the MVD were no prognostic factors in dogs
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EA - Morphology and cytology
OECD FORD branch
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Project
<a href="/en/project/ME09090" target="_blank" >ME09090: Designing quantitative studies in histology - strategies of sampling and detection, testing of reliability and reproducibility</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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