Repeated miscarriages in patients with antiphospholipid syndrome and subjected to in vitro fertilization: the importance of preimplantation genetic diagnosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F12%3A10120308" target="_blank" >RIV/00216208:11140/12:10120308 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1177/0961203312442581" target="_blank" >http://dx.doi.org/10.1177/0961203312442581</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/0961203312442581" target="_blank" >10.1177/0961203312442581</a>

Result language

angličtina

Original language name

Repeated miscarriages in patients with antiphospholipid syndrome and subjected to in vitro fertilization: the importance of preimplantation genetic diagnosis

Original language description

The aim of this study was to investigate two patients with antiphospholipid syndrome (APS) who suffered from multiple repeated pregnancy losses of probably genetically impaired embryos. Sera from these patients contained high levels of IgG antibodies against cardiolipin, IgG and IgM phosphatidyl inositol, IgG phosphatidyl L-serine, and IgG against anti-annexin V. The conventional treatment of APS was ineffective. Preimplantation genetic diagnosis (PGD) showed chromosomally impaired embryos. The course of pregnancies and deliveries were monitored due to the close collaboration of in vitro fertilization and PGD in early embryos. After the selection of normal embryos using PGD, and the treatment of APS, both patients became pregnant and delivered healthybabies. Without such selection, both women would probably have miscarried their embryos again.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FK - Gynaecology and obstetrics

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Lupus

ISSN

0961-2033

e-ISSN

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Volume of the periodical

21

Issue of the periodical within the volume

7

Country of publishing house

GB - UNITED KINGDOM

Number of pages

3

Pages from-to

744-746

UT code for WoS article

000304454200017

EID of the result in the Scopus database

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