Stem cells in the biology of normal urothelium and urothelial carcinoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F12%3A10123791" target="_blank" >RIV/00216208:11140/12:10123791 - isvavai.cz</a>

Result on the web

<a href="http://www.elis.sk/download_file.php?product_id=2994&session_id=jpa5s76uapba31c9g19nl9hbm7" target="_blank" >http://www.elis.sk/download_file.php?product_id=2994&session_id=jpa5s76uapba31c9g19nl9hbm7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/neo_2012_089" target="_blank" >10.4149/neo_2012_089</a>

Result language

angličtina

Original language name

Stem cells in the biology of normal urothelium and urothelial carcinoma

Original language description

Urothelium is a special type of stratified epithelium that lines the distal portion of the urinary tract. For a long time, basal urothelial cells have been suspected to include a population of urothelial stem cells. Recent experiments identifying label-retaining cells as well as lineage tracing analyses corroborate this notion. There are striking morphological and antigenic similarities between basal or differentiated urothelial cells and the corresponding cells in some urothelial carcinomas. In this respect, basal cell-specific markers provide good candidates to identify urothelial carcinoma stem cells, e.g. specific cytokeratins (CK5, CK14, CK17) or adhesion molecules (specific integrin subspecies, CD44). Common properties of the stem cells of normalurothelium and urothelial cancer have thus emerged. Both are characterized by a remarkable plasticity and both rely on reciprocal interactions with stromal fibroblasts. However, the stem cells of individual urothelial carcinomas appear t

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neoplasma

ISSN

0028-2685

e-ISSN

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Volume of the periodical

59

Issue of the periodical within the volume

6

Country of publishing house

SK - SLOVAKIA

Number of pages

9

Pages from-to

728-736

UT code for WoS article

000310820200017

EID of the result in the Scopus database

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