Ovarian cancer stem cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F12%3A10124165" target="_blank" >RIV/00216208:11140/12:10124165 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.4149/neo_2012_094" target="_blank" >http://dx.doi.org/10.4149/neo_2012_094</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/neo_2012_094" target="_blank" >10.4149/neo_2012_094</a>

Result language
angličtina
Original language name
Ovarian cancer stem cells
Original language description
Because of its semi-solid character in dissemination and growth, advanced ovarian cancer appears to be an excellent in vivo model for studying the cancer stem cell hypothesis. The exact nature of these tumor-initiating cells endowed with the properties of anoikis-resistance and unlimited self-renewal is not clear at present, however. Until now, no universal marker(s) has been found to faithfully isolate (ovarian) cancer stem cells. As these multipotent cells are known to possess highly elaborated effluxsystems for cytotoxic agents, these pump systems have been exploited to outline putative stem cells as a side-population (SP) via dye exclusion analysis. An alterantive is to isolate stem cells based on surface markers. In the Vienna variant of the ovarian cancer cell line A2780 a proof-of-principle model with both a stable SP and a stable ALDH1A1+ cell population was established. Double staining clearly revealed that both cell fractions were not identical. Of note, A2780V cells were ne
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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