Asymptomatic abdominal aortic aneurysms show histological signs of progression: A quantitative histochemical analysis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F13%3A10123169" target="_blank" >RIV/00216208:11140/13:10123169 - isvavai.cz</a>

Alternative codes found

RIV/49777513:23520/13:43915266 RIV/00669806:_____/13:10123169

Result on the web

<a href="http://www.karger.com/Article/Pdf/339304" target="_blank" >http://www.karger.com/Article/Pdf/339304</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000339304" target="_blank" >10.1159/000339304</a>

Result language

angličtina

Original language name

Asymptomatic abdominal aortic aneurysms show histological signs of progression: A quantitative histochemical analysis

Original language description

Paper summarizes results of our prospective non-randomized study in the field of quantitative histopathological analysis of the abdominal aortic aneurysms. We evaluated samples of 65 AAA pateints and 55 corresponding thrombi, also 6 normal abdominal aortas. Asymptomatic AAAs had more abundant inflammatory infiltrates, lower amounts of PAI-1, a higher number of tPA-positive elements, a greater concentration of VCAM-1 and MMP-2, and a tendency towards decreased collagen content when compared with symptomatic AAAs. Compared with the aneurysmatic aorta, the normal aorta contained less collagen and more elastin, actin, desmin and PAI-1-positive elements; in addition, it was more vascular. Medium-sized AAAs were the most actin and vimentin rich, and large AAAs were the most vascular. Quantitative microscopy seems to offer a new insight into morphology and pathogenesis of AAA. Our results indicate the rupture-prone nature of the asymptomatic AAAs and support the need for AAA screening program

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EA - Morphology and cytology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pathobiology : journal of immunopathology, molecular and cellular biology

ISSN

1015-2008

e-ISSN

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Volume of the periodical

80

Issue of the periodical within the volume

1

Country of publishing house

CH - SWITZERLAND

Number of pages

13

Pages from-to

11-23

UT code for WoS article

000308125900002

EID of the result in the Scopus database

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